中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2015年
13期
1980-1981,1982
,共3页
神经节苷脂%高压氧%缺氧缺血性脑病,新生儿%神经元特异性烯醇化酶
神經節苷脂%高壓氧%缺氧缺血性腦病,新生兒%神經元特異性烯醇化酶
신경절감지%고압양%결양결혈성뇌병,신생인%신경원특이성희순화매
gangliosides%hyperbaric oxygen%hypoxic ischemic encephalopathy%Serum neuron specific enoli-zation enzymes
目的：探讨神经节苷脂联合高压氧治疗新生儿缺氧缺血性脑病（HIE）的疗效以及对血清神经元特异性烯醇化酶（NSE）的影响。方法将新生儿科收治并确诊的92例 HIE 患儿采用随机数字表法分为两组，每组46例，均给予常规综合治疗，均于入院第3天加用胞磷胆碱治疗，另外观察组在此基础上加用神经节苷脂联合高压氧治疗，观察并比较两组临床治疗效果及治疗前后新生儿神经行为测定（NBNA）评分和血清NSE 水平。结果观察组总有效率为93．48％，显著高于对照组的76．09％（χ2＝10．02，P ＜0．05）；观察组治疗后 NBNA 评分为（38．92±4．10）分，显著高于治疗前（t ＝8．00，P ＜0．05）和对照组（t ＝6．89，P ＜0．05）；而血清 NSE 水平为（9．56±2．03）μg／L，显著低于治疗前（t ＝8．31，P ＜0．05）和对照组（t ＝7．12，P ＜0．05）。结论神经节苷脂联合高压氧治疗 HIE 疗效显著，可明显降低血清 NSE 水平，改善患者神经功能，具有较好的临床应用价值。
目的：探討神經節苷脂聯閤高壓氧治療新生兒缺氧缺血性腦病（HIE）的療效以及對血清神經元特異性烯醇化酶（NSE）的影響。方法將新生兒科收治併確診的92例 HIE 患兒採用隨機數字錶法分為兩組，每組46例，均給予常規綜閤治療，均于入院第3天加用胞燐膽堿治療，另外觀察組在此基礎上加用神經節苷脂聯閤高壓氧治療，觀察併比較兩組臨床治療效果及治療前後新生兒神經行為測定（NBNA）評分和血清NSE 水平。結果觀察組總有效率為93．48％，顯著高于對照組的76．09％（χ2＝10．02，P ＜0．05）；觀察組治療後 NBNA 評分為（38．92±4．10）分，顯著高于治療前（t ＝8．00，P ＜0．05）和對照組（t ＝6．89，P ＜0．05）；而血清 NSE 水平為（9．56±2．03）μg／L，顯著低于治療前（t ＝8．31，P ＜0．05）和對照組（t ＝7．12，P ＜0．05）。結論神經節苷脂聯閤高壓氧治療 HIE 療效顯著，可明顯降低血清 NSE 水平，改善患者神經功能，具有較好的臨床應用價值。
목적：탐토신경절감지연합고압양치료신생인결양결혈성뇌병（HIE）적료효이급대혈청신경원특이성희순화매（NSE）적영향。방법장신생인과수치병학진적92례 HIE 환인채용수궤수자표법분위량조，매조46례，균급여상규종합치료，균우입원제3천가용포린담감치료，령외관찰조재차기출상가용신경절감지연합고압양치료，관찰병비교량조림상치료효과급치료전후신생인신경행위측정（NBNA）평분화혈청NSE 수평。결과관찰조총유효솔위93．48％，현저고우대조조적76．09％（χ2＝10．02，P ＜0．05）；관찰조치료후 NBNA 평분위（38．92±4．10）분，현저고우치료전（t ＝8．00，P ＜0．05）화대조조（t ＝6．89，P ＜0．05）；이혈청 NSE 수평위（9．56±2．03）μg／L，현저저우치료전（t ＝8．31，P ＜0．05）화대조조（t ＝7．12，P ＜0．05）。결론신경절감지연합고압양치료 HIE 료효현저，가명현강저혈청 NSE 수평，개선환자신경공능，구유교호적림상응용개치。
Objective To investigate the curative effect of ganglioside combined with hyperbaric oxygen in treatment of neonatal hypoxic ischemic encephalopathy (HIE)and its influence on serum neuronspecific enolase (NSE).Methods 92 cases of children with HIE were randomly divided into two groups,each group in 46 cases. They were all given routine therapy,and added the citicoline for treatment at third day after being hospitalized,and the observation group were treated with ganglion ganglioside combined with hyperbaric oxygen on the basis of that.Clinical treatment effect and neonatal behavioral neurological(NBNA)scores,serum neuron specific enolase (NSE)levels of the two groups before and after treatment were observed and compared.Results The total effective rate of the obser-vation group was 93.48%,which was significantly higher than 76.09% of the control group (χ2 =10.02,P <0.05);NBNA score of the observation group after treatment were (38.92 ±4.10)points,which was significantly higher than that before treatment (t =8.00,P <0.05)and the control group (t =6.89,P <0.05);while its serum NSE was (9.56 ± 2.03)μg/L,which was significantly lower than before treatment(t =8.31,P <0.05)and the control group(t =7.12, P <0.05).Conclusion The ganglioside combined with hyperbaric oxygen therapy has a significant effect for hypoxic ischemic encephalopathy,which can significantly decrease the serum NSE level,improve neurological function and has a better clinical application value.
