CAJ | 학술논문

目的：探讨曲妥珠单抗联合放疗同步应用于乳腺癌术后辅助治疗的疗效和安全性。方法76例乳腺癌术后患者随机分为2组，试验组40例采用曲妥珠单抗同步放疗，对照组采用放疗和曲妥珠单抗序贯治疗。结果2组患者的心脏安全性良好，共出现心脏不良事件7例（9.2％），其中试验组5例（12.5％），对照组2例（5.6％），比较差异无统计学意义（ P＞0.05）；9例（11.8％）出现复发转移，其中试验组4例（10.00％），对照组5例（13.89％），比较差异无统计学意义（ P＞0.05）。2组患者的无病生存时间比较差异无统计学意义（ P＞0.05）。结论在乳腺癌术后辅助治疗中，曲妥珠单抗联合放疗同步应用并不增加患者心脏不良事件的风险，安全性良好。
목적：탐토곡타주단항연합방료동보응용우유선암술후보조치료적료효화안전성。방법76례유선암술후환자수궤분위2조，시험조40례채용곡타주단항동보방료，대조조채용방료화곡타주단항서관치료。결과2조환자적심장안전성량호，공출현심장불량사건7례（9.2％），기중시험조5례（12.5％），대조조2례（5.6％），비교차이무통계학의의（ P＞0.05）；9례（11.8％）출현복발전이，기중시험조4례（10.00％），대조조5례（13.89％），비교차이무통계학의의（ P＞0.05）。2조환자적무병생존시간비교차이무통계학의의（ P＞0.05）。결론재유선암술후보조치료중，곡타주단항연합방료동보응용병불증가환자심장불량사건적풍험，안전성량호。
Objective Toinvestigatetheefficacyandsafetyoftrastuzumabcombinedwithsynchronousradio-therapyinthepostoperativeadjuvanttreatmentofbreastcancer.Methods Seventy-sixpostoperativepatientswith breast cancer were randomly divided into the experimental group and the control group,the 40 patients of the experi-mental group received the synchronous trastuzumab and radiotherapy,36 patients of the control group were used with radiotherapyandtrastuzumabsequentialtreatment.Results Thecardiacsafetyofthetwogroupswasgood,adverse cardiac events were observed in the 7 patients(9. 2%),included 5 patients(12. 5%)of the experimental group and 2 patients(5. 6%)of the control group,there were no significant difference(P>0. 05);9 patients(11. 8%) appeared the recurrence and metastasis,included 4 patients(10. 0%)in the experimental group and 5 patients (13. 89%)in the control group,no statistically significant difference was observed between the two groups( P>0. 05). No statistically significant difference was observed in the disease free survival between the two groups(P>0.05).Conclusion Ⅰnthepostoperativeadjuvanttreatmentofbreastcancer,trastuzumabcombinedwithsynchro-nous radiotherapy do not increase the risk of cardiac adverse events,and safety is good.