肿瘤基础与临床
腫瘤基礎與臨床
종류기출여림상
JOURNAL OF BASIC AND CLINICAL ONCOLOGY
2015年
3期
188-189
,共2页
郑伟%王素萍%吉木斯%崔淑贞
鄭偉%王素萍%吉木斯%崔淑貞
정위%왕소평%길목사%최숙정
转化生长因子β1%子宫内膜样腺癌%临床病理特征
轉化生長因子β1%子宮內膜樣腺癌%臨床病理特徵
전화생장인자β1%자궁내막양선암%림상병리특정
transforming growth factor β1%endometrioid adenocarcinoma%clinicopathological feature
目的:探讨转化生长因子β1(TGFβ1)在子宫内膜样腺癌组织的表达及意义。方法应用免疫组化S-P法检测TGFβ1在64例子宫内膜样腺癌组织和20例正常子宫内膜组织中的表达。结果子宫内膜样腺癌组织中TGFβ1的阳性率为93.75%,高于正常子宫内膜组织的30.00%(P<0.05)。子宫内膜样腺癌组织中TGFβ1的表达与其病理分级有关(P<0.05)。结论 TGFβ1表达增高能促进子宫内膜样腺癌的进展。
目的:探討轉化生長因子β1(TGFβ1)在子宮內膜樣腺癌組織的錶達及意義。方法應用免疫組化S-P法檢測TGFβ1在64例子宮內膜樣腺癌組織和20例正常子宮內膜組織中的錶達。結果子宮內膜樣腺癌組織中TGFβ1的暘性率為93.75%,高于正常子宮內膜組織的30.00%(P<0.05)。子宮內膜樣腺癌組織中TGFβ1的錶達與其病理分級有關(P<0.05)。結論 TGFβ1錶達增高能促進子宮內膜樣腺癌的進展。
목적:탐토전화생장인자β1(TGFβ1)재자궁내막양선암조직적표체급의의。방법응용면역조화S-P법검측TGFβ1재64례자궁내막양선암조직화20례정상자궁내막조직중적표체。결과자궁내막양선암조직중TGFβ1적양성솔위93.75%,고우정상자궁내막조직적30.00%(P<0.05)。자궁내막양선암조직중TGFβ1적표체여기병리분급유관(P<0.05)。결론 TGFβ1표체증고능촉진자궁내막양선암적진전。
Objective Toinvestigatetheexpressionandclinicalsignificanceoftransforminggrowthfactorβ1 (TGFβ1)intheendometrioidadenocarcinoma.Methods TheexpressionsofTGFβ1inthe64patientswithendo-metrioid adenocarcinoma and 20 patients with normal endometrium were evaluated by immunohistochemistry S-P method.Results TheTGFβ1positiverateoftheendometrioidadenocarcinomawashigherthanthatoftheendome-trium(93. 75% vs 30. 00%,P<0. 05). The expression of TGFβ1 in the endometrioid adenocarcinoma was related tothepathologicalgrading(P<0.05).Conclusion TheincreasingexpressionofTGFβ1couldacceleratethegen-eration and development of endometrioid adenocarcinoma.