CAJ | 학술논문

目的:探讨白三烯( letukotriene)在寻常痤疮发病机制中的作用. 方法:对65例寻常痤疮患者及40例正常人血清中的白三烯浓度进行检测分析. 结果:寻常痤疮患者组血清LTB4浓度高于对照组,差异有统计学意义( P<0.05). 寻常痤疮患者组血清LTC4、LTE4浓度与对照组比较差异无统计学意义( P>0.05). 各级痤疮患者组与对照组血清LTB4的比较差异有统计学意义( P<0.05或P<0.01) ,各级痤疮患者组与对照组血清LTC4、LTE4的比较差异无统计学意义( P>0.05). 组间比较:各级痤疮患者组血清LTB4、LTC4、LTE4的两两比较差异均无统计学意义( P>0.05). 结论:白三烯B4可能在寻常痤疮发病中起重要作用,但与寻常痤疮的病情轻重程度无关. 白三烯C4、白三烯E4可能未参与痤疮的炎症过程.
목적:탐토백삼희( letukotriene)재심상좌창발병궤제중적작용. 방법:대65례심상좌창환자급40례정상인혈청중적백삼희농도진행검측분석. 결과:심상좌창환자조혈청LTB4농도고우대조조,차이유통계학의의( P<0.05). 심상좌창환자조혈청LTC4、LTE4농도여대조조비교차이무통계학의의( P>0.05). 각급좌창환자조여대조조혈청LTB4적비교차이유통계학의의( P<0.05혹P<0.01) ,각급좌창환자조여대조조혈청LTC4、LTE4적비교차이무통계학의의( P>0.05). 조간비교:각급좌창환자조혈청LTB4、LTC4、LTE4적량량비교차이균무통계학의의( P>0.05). 결론:백삼희B4가능재심상좌창발병중기중요작용,단여심상좌창적병정경중정도무관. 백삼희C4、백삼희E4가능미삼여좌창적염증과정.
Objective:To study the role of letukotriene in the pathogenesis of acne vulgaris.Method:The levels of letukotriene B4, letukotriene C4, letukotriene E4 in serum from 65 patients with acne vulgaris and 40 normal controls were analyzed.Result:The serum levels of letukotriene B4 in acne vulgaris were sig-nificantly higher than those in normal controls( P<0.05) ;There were no significant differences in letukot-riene C4 and letukotriene E4 levels between the patients with acne vulgaris and those normal controls ; but there were no significant differences in letukotriene B4, letukotrieneC4, letukotriene E4 levels between the patients with different degrees of acne vulgaris.Conclusion:The findings indicate that letukotriene B4 may be closely assoiated with the pathogenesis of acne vulgaris.