河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
9期
1468-1471
,共4页
恶性肿瘤%贫血%重组人促红细胞生成素
噁性腫瘤%貧血%重組人促紅細胞生成素
악성종류%빈혈%중조인촉홍세포생성소
Malignant tumor%Anemia%Erythropoietin
目的:探讨重组人促红素在恶性肿瘤伴贫血治疗中的临床药物疗效. 方法:将2011年2月至2013年1月本院确诊的60例恶性肿瘤伴贫血患者随机分成两组:实验组30例;对照组30例.对照组采用右旋糖酐铁注射液加叶酸加维生素B12治疗;实验组在对照组治疗基础上再给予重组人促红细胞生成素治疗. 观察比较两组的临床疗效、血液指标水平、卡氏评分和不良反应发生情况. 结果:两组总有效率比较发现实验组的93.33%明显优于对照组的70.00%,两组比较χ2=5.45,P<0.05.两组的血红蛋白(Hb)、红细胞压积(HCT)、红细胞计数(RBC)、血小板(PLT)指标均较治疗前改善(P<0.05) ,其中实验组改善的幅度更为明显,与对照组比较( P<0.05). 两组服药后产生的不良反应发生率相当,无显著性差异( P>0.05);实验组的Karnofsky评分显著性优于对照组( P<0.05). 结论:临床上应用重组人促红素联合铁剂、叶酸、维生素B12治疗恶性肿瘤伴贫血的药物疗效显著.
目的:探討重組人促紅素在噁性腫瘤伴貧血治療中的臨床藥物療效. 方法:將2011年2月至2013年1月本院確診的60例噁性腫瘤伴貧血患者隨機分成兩組:實驗組30例;對照組30例.對照組採用右鏇糖酐鐵註射液加葉痠加維生素B12治療;實驗組在對照組治療基礎上再給予重組人促紅細胞生成素治療. 觀察比較兩組的臨床療效、血液指標水平、卡氏評分和不良反應髮生情況. 結果:兩組總有效率比較髮現實驗組的93.33%明顯優于對照組的70.00%,兩組比較χ2=5.45,P<0.05.兩組的血紅蛋白(Hb)、紅細胞壓積(HCT)、紅細胞計數(RBC)、血小闆(PLT)指標均較治療前改善(P<0.05) ,其中實驗組改善的幅度更為明顯,與對照組比較( P<0.05). 兩組服藥後產生的不良反應髮生率相噹,無顯著性差異( P>0.05);實驗組的Karnofsky評分顯著性優于對照組( P<0.05). 結論:臨床上應用重組人促紅素聯閤鐵劑、葉痠、維生素B12治療噁性腫瘤伴貧血的藥物療效顯著.
목적:탐토중조인촉홍소재악성종류반빈혈치료중적림상약물료효. 방법:장2011년2월지2013년1월본원학진적60례악성종류반빈혈환자수궤분성량조:실험조30례;대조조30례.대조조채용우선당항철주사액가협산가유생소B12치료;실험조재대조조치료기출상재급여중조인촉홍세포생성소치료. 관찰비교량조적림상료효、혈액지표수평、잡씨평분화불량반응발생정황. 결과:량조총유효솔비교발현실험조적93.33%명현우우대조조적70.00%,량조비교χ2=5.45,P<0.05.량조적혈홍단백(Hb)、홍세포압적(HCT)、홍세포계수(RBC)、혈소판(PLT)지표균교치료전개선(P<0.05) ,기중실험조개선적폭도경위명현,여대조조비교( P<0.05). 량조복약후산생적불량반응발생솔상당,무현저성차이( P>0.05);실험조적Karnofsky평분현저성우우대조조( P<0.05). 결론:림상상응용중조인촉홍소연합철제、협산、유생소B12치료악성종류반빈혈적약물료효현저.
Objective:To study the drug efficacy of erythropoietin in the treatment of malignant tumor with anemia.Method:60 patients cases malignant tumor with anemia in our hospital during February 2009 to January 2009, They were randomly divided into 2 groups:30 cases in the experimental group, 30 cases in the control group.The control group used the treatment of iron-dextran injection, folic acid and vitamin B12;the experimental group were given erythropoietin therapy on the basic of the control group.Compared the clinical efficacy, blood index level, Karnofsky scores, and adverse reactions of the two groups.Result:The total effective rate of the experimental group was 93.33%, the total effective rate of the control group was 70. 00%, total effective rate of the experimental group was significantly higher than those of the control group ( P<0.05);the hemoglobin ( Hb) , hematokrit ( HCT) , RBC count ( RBC) and platelet ( PLT) index levels of experimental group were significantly higher than that of control group ( P <0.05);compared with the con-trol group were, The total incidence of adverse reactions of the experimental group, with no significant differ-ences ( P >0.05);The Karnofsky scores of the experimental group were significantly better than that of con-trol group ( P <0.05) .Conclusion:The curative effect of erythropoietin combined iron, folic acid and vita-min B12 in the treatment of malignant tumor with anemia is significant.
