河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
9期
1429-1433
,共5页
心肌梗死%心衰%超敏C反应蛋白%前白蛋白
心肌梗死%心衰%超敏C反應蛋白%前白蛋白
심기경사%심쇠%초민C반응단백%전백단백
Myocardial infarction%Heart failure%High-sensitivity C-reactive protein%Prealbu-min
目的:探索血清超敏C反应蛋白与前白蛋白比值( hs-CRP/P AB )对急性心肌梗死患者发生心力衰竭的预测价值. 方法:2011年1月至2014年1月于我院住院并确诊的心肌梗死者200例,根据Killip心功能分级标分为心衰组( 122例);非心衰组( 78例). 比较两组患者一般临床资料与个生化指标(肌钙蛋白T、肌酸激酶同工酶、NT-pro-BNP、hs-CRP、PAB)的差别. 采用Spearman相关、Logistic回归及ROC曲线对相关数据进行统计分析. 结果:与非心衰组相比,心衰组hs-CRP 水平升高,而PAB水平下降,ln(hs-CRP/PAB)值升高,(P<0.05). Spearnnan相关分析提示心力衰竭患者hs-CRP/PAB与Killip 分级正相关(rhs-CRP/PAB=-0.392,P=0.003). ROC 曲线分析提示,ln(hs-CRP/PAB)预测AHF发生的曲线下面积(AUC)为0736,95%CI(0.675~0.831). 结论:血清hs-CRP/P AB是心肌梗死患者发生心力衰竭的独立预测因素,其水平越高发生心衰的风险越大、症状越重.
目的:探索血清超敏C反應蛋白與前白蛋白比值( hs-CRP/P AB )對急性心肌梗死患者髮生心力衰竭的預測價值. 方法:2011年1月至2014年1月于我院住院併確診的心肌梗死者200例,根據Killip心功能分級標分為心衰組( 122例);非心衰組( 78例). 比較兩組患者一般臨床資料與箇生化指標(肌鈣蛋白T、肌痠激酶同工酶、NT-pro-BNP、hs-CRP、PAB)的差彆. 採用Spearman相關、Logistic迴歸及ROC麯線對相關數據進行統計分析. 結果:與非心衰組相比,心衰組hs-CRP 水平升高,而PAB水平下降,ln(hs-CRP/PAB)值升高,(P<0.05). Spearnnan相關分析提示心力衰竭患者hs-CRP/PAB與Killip 分級正相關(rhs-CRP/PAB=-0.392,P=0.003). ROC 麯線分析提示,ln(hs-CRP/PAB)預測AHF髮生的麯線下麵積(AUC)為0736,95%CI(0.675~0.831). 結論:血清hs-CRP/P AB是心肌梗死患者髮生心力衰竭的獨立預測因素,其水平越高髮生心衰的風險越大、癥狀越重.
목적:탐색혈청초민C반응단백여전백단백비치( hs-CRP/P AB )대급성심기경사환자발생심력쇠갈적예측개치. 방법:2011년1월지2014년1월우아원주원병학진적심기경사자200례,근거Killip심공능분급표분위심쇠조( 122례);비심쇠조( 78례). 비교량조환자일반림상자료여개생화지표(기개단백T、기산격매동공매、NT-pro-BNP、hs-CRP、PAB)적차별. 채용Spearman상관、Logistic회귀급ROC곡선대상관수거진행통계분석. 결과:여비심쇠조상비,심쇠조hs-CRP 수평승고,이PAB수평하강,ln(hs-CRP/PAB)치승고,(P<0.05). Spearnnan상관분석제시심력쇠갈환자hs-CRP/PAB여Killip 분급정상관(rhs-CRP/PAB=-0.392,P=0.003). ROC 곡선분석제시,ln(hs-CRP/PAB)예측AHF발생적곡선하면적(AUC)위0736,95%CI(0.675~0.831). 결론:혈청hs-CRP/P AB시심기경사환자발생심력쇠갈적독립예측인소,기수평월고발생심쇠적풍험월대、증상월중.
Objective:To explore the predictive value of the ratio of serum high -sensitivity C-reactive protein to prealbumin ( hs-CRP /PAB) for heart failure in patients with acute myocardial infarction ( AMI) . Method:200 AMI patients, from Jan.2011 to Jan.2014 in our hospital, were enrolled.According to Killip classification standard, patients were divided into heart failure group ( 122 cases ) and non-heart failure group (78 cases).Clinical data and biochemical indicators (troponin T, creatine kinase MB, NT-pro-BNP, hs-CRP, PAB) were compared in two groups.Data was analysed by Spearman correlation, Logistic Regression and ROC curv.Result:Compared with non-heart failure group, levels of hs-CRP was elevated in heart failure group, levels of PAB dropped, value of ln ( hs-CRP /PAB) increased in heart failure group ( P <0.05) . Spearnnan correlation analysis showed that hs-CRP /PAB positively correlated with Killip class ( rhs-CRP /PAB =-0.392, P =0.003) .ROC curve analysis showed that the area under the ROC curve of ln (hs-CRP /PAB) predicting AHF was 0.736, 95%CI (0.675 ~0.831).Conclusion:The level of hs-CRP /PAB is an independent predictor for heart failure in patients with myocardial infarction, and is posi-tively correlated with severity of heart failure.
