河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
9期
1409-1413
,共5页
CHD5%WWOX%胃癌%免疫组化法%预后
CHD5%WWOX%胃癌%免疫組化法%預後
CHD5%WWOX%위암%면역조화법%예후
Chromodomain helicase DNA-binding protein 5%WW domain-containing oxidoreduc-tase%Gastric carcinoma%Immunohistochemistry%Prognosis
目的:探讨抑癌基因CHD5和WWOX的蛋白在胃癌中的表达及其对预后的影响. 方法:随机选取我院收治的胃癌患者65 例,采用免疫组化法检测胃癌组织及相应癌旁组织 CHD5 和WWOX蛋白的表达及与预后的关系. 结果:CHD5和WWOX蛋白在胃癌组织中的阳性表达率分别为36.92%(24/65)和41.54%(27/65),明显低于在癌旁组织的(P<0.05). 在胃癌组织中,CHD5 和WWOX蛋白的表达与TNM分期、肿瘤分化程度及淋巴结转移均有关( P<0.05). 生存分析Kaplan-Meier法显示,CHD5和WWOX蛋白阳性表达的患者1、3年生存率显著高于阴性表达的患者,差异均有统计学意义( P<0.05). 结论:CHD5和WWOX在胃癌组织中低表达与胃癌的病变程度、侵袭转移及预后不良关系密切,提示CHD5和WWOX蛋白低表达可能参与胃癌的发生、发展及胃黏膜恶性转变等过程.
目的:探討抑癌基因CHD5和WWOX的蛋白在胃癌中的錶達及其對預後的影響. 方法:隨機選取我院收治的胃癌患者65 例,採用免疫組化法檢測胃癌組織及相應癌徬組織 CHD5 和WWOX蛋白的錶達及與預後的關繫. 結果:CHD5和WWOX蛋白在胃癌組織中的暘性錶達率分彆為36.92%(24/65)和41.54%(27/65),明顯低于在癌徬組織的(P<0.05). 在胃癌組織中,CHD5 和WWOX蛋白的錶達與TNM分期、腫瘤分化程度及淋巴結轉移均有關( P<0.05). 生存分析Kaplan-Meier法顯示,CHD5和WWOX蛋白暘性錶達的患者1、3年生存率顯著高于陰性錶達的患者,差異均有統計學意義( P<0.05). 結論:CHD5和WWOX在胃癌組織中低錶達與胃癌的病變程度、侵襲轉移及預後不良關繫密切,提示CHD5和WWOX蛋白低錶達可能參與胃癌的髮生、髮展及胃黏膜噁性轉變等過程.
목적:탐토억암기인CHD5화WWOX적단백재위암중적표체급기대예후적영향. 방법:수궤선취아원수치적위암환자65 례,채용면역조화법검측위암조직급상응암방조직 CHD5 화WWOX단백적표체급여예후적관계. 결과:CHD5화WWOX단백재위암조직중적양성표체솔분별위36.92%(24/65)화41.54%(27/65),명현저우재암방조직적(P<0.05). 재위암조직중,CHD5 화WWOX단백적표체여TNM분기、종류분화정도급림파결전이균유관( P<0.05). 생존분석Kaplan-Meier법현시,CHD5화WWOX단백양성표체적환자1、3년생존솔현저고우음성표체적환자,차이균유통계학의의( P<0.05). 결론:CHD5화WWOX재위암조직중저표체여위암적병변정도、침습전이급예후불량관계밀절,제시CHD5화WWOX단백저표체가능삼여위암적발생、발전급위점막악성전변등과정.
Objective:To discuss the expression of CHD5 and WWOX in gastric carcinoma and its in-fluence on prognosis.Method:65 cases of patients with gastric cancer were randomly selected from our hos-pital.Immunohistochemistry was used to detect the expression of CHD5 protein and WWOX protein in the gastric cancer tissues and matched tumor-adjacent gastric tissues and the influence on prognosis.Result:The positive rate of CHD5 protein and WWOX protein expression in gastric cancer tissues were 36.92%(24/65) and 41.54%(27/65), which were significantly lower than that in matched tumor-adjacent gastric tissues(P<0.05) .The expression of CHD5 protein and WWOX protein were correlated with TNM stage, histologic dif-ferentiation and lymph node metastasis( P<0.05) .The Kaplan-Meier plot showed that the cumulative 1-and 3-year survival rates were significantly higher in patients with positive expression of CHD5 and WWOX than those with negative expression of these two proteins ( P<0.05 ) .Conclusion:Reduced expression of CHD5and WWOX in gastric cancer is associated with tumor malignancy,invasiveness and poor survival.Reduced expression of CHD5 and WWOX proteins may play an important role in the tumorigenesis and progression of gastric carcinoma.
