中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2015年
13期
1924-1926
,共3页
子宫内膜异常%子宫内膜微创术%多囊卵巢综合征%促排卵
子宮內膜異常%子宮內膜微創術%多囊卵巢綜閤徵%促排卵
자궁내막이상%자궁내막미창술%다낭란소종합정%촉배란
Abnormality endometrium%Endometrium microresecting%Polycystic ovary syndrome%Induetion of ovulation
目的：观察子宫内膜微创预处理在多囊卵巢综合征（PCOS）不孕患者促排卵治疗中的疗效。方法选择66例在自然月经周期的晚卵泡期超声提示子宫内膜回声紊乱及异常增厚的 PCOS 育龄期不孕症患者，按数字表法随机分为研究组与对照组各33例。患者均用屈罗酮炔雌醇片治疗3～6个周期后，用氯米芬（CC）促排卵治疗，研究组于月经来潮3～5 d 内，用一次性宫腔组织吸引管对子宫内膜行微创预处理，对照组不行内膜微创预处理，两组患者均给予雌激素及黄体酮治疗，结合 B 超监测卵泡及子宫内膜厚度。结果研究组子宫内膜厚度（8．78±1．56）mm，妊娠率36．36％，流产率16．67％，手术操作时无明显疼痛不适，无感染发生；对照组内膜厚度（6．32±0．74）mm，妊娠率24．24％，流产率12．50％。两组内膜厚度、妊娠率差异有统计学意义（t ＝8．184，χ2＝4．60，均 P ＜0．05）。结论一次性宫腔组织吸引管对子宫内膜进行微创预处理，可增加子宫内膜厚度，提高妊娠率，不增加早期流产率，且有易于操作、方便、创伤小、痛苦小、易接受等优点。
目的：觀察子宮內膜微創預處理在多囊卵巢綜閤徵（PCOS）不孕患者促排卵治療中的療效。方法選擇66例在自然月經週期的晚卵泡期超聲提示子宮內膜迴聲紊亂及異常增厚的 PCOS 育齡期不孕癥患者，按數字錶法隨機分為研究組與對照組各33例。患者均用屈囉酮炔雌醇片治療3～6箇週期後，用氯米芬（CC）促排卵治療，研究組于月經來潮3～5 d 內，用一次性宮腔組織吸引管對子宮內膜行微創預處理，對照組不行內膜微創預處理，兩組患者均給予雌激素及黃體酮治療，結閤 B 超鑑測卵泡及子宮內膜厚度。結果研究組子宮內膜厚度（8．78±1．56）mm，妊娠率36．36％，流產率16．67％，手術操作時無明顯疼痛不適，無感染髮生；對照組內膜厚度（6．32±0．74）mm，妊娠率24．24％，流產率12．50％。兩組內膜厚度、妊娠率差異有統計學意義（t ＝8．184，χ2＝4．60，均 P ＜0．05）。結論一次性宮腔組織吸引管對子宮內膜進行微創預處理，可增加子宮內膜厚度，提高妊娠率，不增加早期流產率，且有易于操作、方便、創傷小、痛苦小、易接受等優點。
목적：관찰자궁내막미창예처리재다낭란소종합정（PCOS）불잉환자촉배란치료중적료효。방법선택66례재자연월경주기적만란포기초성제시자궁내막회성문란급이상증후적 PCOS 육령기불잉증환자，안수자표법수궤분위연구조여대조조각33례。환자균용굴라동결자순편치료3～6개주기후，용록미분（CC）촉배란치료，연구조우월경래조3～5 d 내，용일차성궁강조직흡인관대자궁내막행미창예처리，대조조불행내막미창예처리，량조환자균급여자격소급황체동치료，결합 B 초감측란포급자궁내막후도。결과연구조자궁내막후도（8．78±1．56）mm，임신솔36．36％，유산솔16．67％，수술조작시무명현동통불괄，무감염발생；대조조내막후도（6．32±0．74）mm，임신솔24．24％，유산솔12．50％。량조내막후도、임신솔차이유통계학의의（t ＝8．184，χ2＝4．60，균 P ＜0．05）。결론일차성궁강조직흡인관대자궁내막진행미창예처리，가증가자궁내막후도，제고임신솔，불증가조기유산솔，차유역우조작、방편、창상소、통고소、역접수등우점。
Objective To observe the therapeutic effect of endometrium minimally invasive pretreatment on non -pregnant PCOS patients who are on ovulation induction treatment.Methods According to the digital meter method,divided 66 non -pregnant PCOS patients who were with abnormal endometrial echoes or abnormal thickening by ultrasound in follicular phase in natural periodwith into testing group(33 cases)and control group(33 cases).All patients were treated with drospirenone and ethinylestradiol tablets treatment for 3 to 6 cycles,and then with clomi-phene citrate(CC)for induction of ovulation.In the testing group,endometrium microresecting was given by disposa-ble uterine cavity tissue suction tube device within 3 ~5days after menstrual onset.Patients in the control group were not performed with endometrium microresecting.All patients of the two groups were given estrogen and progesteroneas well as detection of ovarian folicle and endom etrium with B -modeult rasonography.Results Intimal thickness in the testing group was(8.78 ±1.56)mm,the pregnancy rate was 36.36% and the abortion rate was 16.67%,there was no obvious pain and unwell during the operation and the patients were free from infection.Intimal thickness in the testing group was(6.32 ±0.74)mm,the pregnancy rate was 24.24% and the abortion rate was 12.50%.There were significant differences between the two groups of endometrial thickness,pregnancy rate(t =8.184,χ2 =4.60,all P <0.05).Conclusion Endometrium microresecting by endometrial sampling device can increase the endometrium, thickness and the pregnancy rate,and at the same time it doesnot increase the rate of early spontaneous abortion.And it is easy to perate,convenient,less trauma,less pain,easy to acceptand and some other advantages,it has better clini-cal application value,so it deserves to be applied in basic hospital.
