CAJ | 학술논문

目的：探讨低清蛋白（Alb）血、高胆红素血对糖化血清蛋白（GSP）测定结果的影响。为临床诊断糖尿病（DM ）、监测血糖控制水平提供可靠的参考数据。方法根据需要分3组：正常对照组选择健康体检者80例；低A lb试验选择被临床初诊为DM的患者159例，其中Alb正常的DM患者83例为DM组，Alb降低的糖尿病肾病（DN ）患者76例为DN组；高胆红素组选择总胆红素增高而Alb和葡萄糖均正常的患者186例。采用贝克曼AU2700全自动生化分析仪测定GSP、Alb、总胆红素（TBIL）和血糖等水平。分析GSP的水平与TBIL的关系。结果（1）DM组GSP明显高于正常对照组和DM组（P＜0．01），而DN组GSP明显低于正常对照组（P＜0．01）。（2）采用直线相关分析发现，GSP的水平与 TBIL呈正相关（r2＝0．434，P＜0．01）。结论血Alb测定值低于40．0 g／L ，或者TBIL高于55．0μmol／L ，用硝基四氮唑蓝显色法测定GSP不能作为判断患者短期（2～3周）体内血糖的平均水平，应结合临床和糖化血红蛋白来评估。
목적：탐토저청단백（Alb）혈、고담홍소혈대당화혈청단백（GSP）측정결과적영향。위림상진단당뇨병（DM ）、감측혈당공제수평제공가고적삼고수거。방법근거수요분3조：정상대조조선택건강체검자80례；저A lb시험선택피림상초진위DM적환자159례，기중Alb정상적DM환자83례위DM조，Alb강저적당뇨병신병（DN ）환자76례위DN조；고담홍소조선택총담홍소증고이Alb화포도당균정상적환자186례。채용패극만AU2700전자동생화분석의측정GSP、Alb、총담홍소（TBIL）화혈당등수평。분석GSP적수평여TBIL적관계。결과（1）DM조GSP명현고우정상대조조화DM조（P＜0．01），이DN조GSP명현저우정상대조조（P＜0．01）。（2）채용직선상관분석발현，GSP적수평여 TBIL정정상관（r2＝0．434，P＜0．01）。결론혈Alb측정치저우40．0 g／L ，혹자TBIL고우55．0μmol／L ，용초기사담서람현색법측정GSP불능작위판단환자단기（2～3주）체내혈당적평균수평，응결합림상화당화혈홍단백래평고。
Objective To explore the effect of hypoalbuminemia ,hyperbilirubinemia on determination of glycosylated serum protein(GSP) ,and then provide reliable reference data for clinical diagnosis and monitoring of blood glucose control level .Methods According to the need ,all cases were divided into 3 groups .Eighty healthy individuals were chosen as the normal control group . A total of 159 cases who have been initially diagnosed with diabetes were selected for low Alb test ,including 83 cases of diabetic pa‐tients with normal Alb(DM group) and 76 diabetic nephropathy patients with hypoalbuminemia(DN group) .The patients with hy‐perbilirubinemia ,but being normal in Alb and glucose were selected as hyperbilirubinemia group .Beckman AU2700 automatic bio‐chemical analyzer was used to determine of GSP ,Alb ,total bilirubin(TBIL) and blood sugar levels .Results (1)The Welch′s cor‐rection t test analysis showed that the GSP levels in DM group were significantly higher than those in normal control group (P<0 .01) .On the contrary ,the GSP in DN group was lower than that of normal control group and DM group(P<0 .01) .(2)The linear correlation analysis showed that the level of GSP was positively correlated with TBIL(r2 =0 .434 ,P<0 .01) .Conclusion Either the concentration of serum Alb is lower than 40 .0 g/L ,or the measured value of TBIL is higher than 55 .0μmol/L ,the determination of GSP prote with nitro blue tetrazolium colorimetric method can not be used to judge in short‐term (2 to 3 weeks) average blood glu‐cose level .The assessment of blood glucose level should be combined with clinical or determination of glycosylated hemoglobin .