CAJ | 학술논문

目的：探讨S100B与颈动脉粥样硬化稳定性之间的关系。方法收集来自成都市第七人民医院神经内科门诊及住院的颈动脉粥样硬化（CAS）患者200例并根据颈动脉超声结果进一步将患者分为稳定斑块组（105例）及易损斑块组（95例）2组，以ELISA法测定患者血浆中S100B、hs‐CRP水平，并与年龄及性别匹配的198例正常对照组比较。结果S100B水平在易损斑块组中较稳定斑块组及正常对照组明显升高（P＜0．01）；而在稳定斑块组与正常对照组之间S100B差异无统计学意义（P＝0．07）；hs‐CRP在易损斑块组中较稳定斑块组及正常对照组明显的升高（P＜0．01），而在稳定斑块与正常对照组之间差异无统计学意义（P＝0．59）。结论S100B在易损斑块CAS患者组中明显升高，S100B可能参与了CAS斑块的形成，调节S100B可能成为抗CAS的新靶点。
목적：탐토S100B여경동맥죽양경화은정성지간적관계。방법수집래자성도시제칠인민의원신경내과문진급주원적경동맥죽양경화（CAS）환자200례병근거경동맥초성결과진일보장환자분위은정반괴조（105례）급역손반괴조（95례）2조，이ELISA법측정환자혈장중S100B、hs‐CRP수평，병여년령급성별필배적198례정상대조조비교。결과S100B수평재역손반괴조중교은정반괴조급정상대조조명현승고（P＜0．01）；이재은정반괴조여정상대조조지간S100B차이무통계학의의（P＝0．07）；hs‐CRP재역손반괴조중교은정반괴조급정상대조조명현적승고（P＜0．01），이재은정반괴여정상대조조지간차이무통계학의의（P＝0．59）。결론S100B재역손반괴CAS환자조중명현승고，S100B가능삼여료CAS반괴적형성，조절S100B가능성위항CAS적신파점。
Objective To investigate the correlation between S100B protein and the stability of carotid artery arteriosclero‐sis .Methods A total of 200 patients with carotid artery arteriosclerosis(CAS) were assigned as study group ,and then subdivided into stable plaques (SP)group and instable plaques (IP)group ,and 198 whoes age and gender well matched unrelated healthy sub‐jects were enrolled as control group .The levels of S100B and hs‐CRP of the 3 groups were measured by ELESA .All the diagnosis were confirmed by color Doppler and B‐ultrasound .Results The level of serum S100B was significantly higher in IP group than that of SP group and control group(P<0 .01) .There was no statistical significance between IP and SP group in the level of serum S100B(P=0 .07) .The level of hs‐CRP was significantly higher in IP group than that of SP group and control group(P<0 .01) . There was no statistical significance between IP and SP group in the level of serum hs‐CRP(P=0 .59) .Conclusion The increase of serum level of S100B in the IP CAS patients shows that S100B may take part in the pathogenic mechanism of CAS ,and regulating of S100B may become the potential therapeutic targets for CAS .