CAJ | 학술논문

目的：探讨阿司匹林联合氯吡格雷治疗不稳定型心绞痛的疗效及治疗前后血脂与血液黏稠度的变化。方法不稳定型心绞痛患者共120例，随机分为两组，两组患者均给予低分子肝素、阿司匹林等抗栓治疗。实验组在对照组基础上加用氯吡格雷治疗。治疗前后检测血流变学、脂质变化。统计学处理运用统计软件SPSS 19.0进行处理，所获数据采用方差分析，t检验和??2检验。结果实验组有效率91.67%。对照组有效率为65.00%。两组有效率比较，P<0.005，有非常显著性差异。两组治疗后24 h动态心电图对比（P<0.05）有显著性差异。血脂及血流变学均有显著的恢复P均<0.01。结论阿司匹林联合氯吡格雷治疗不稳定型心绞痛的疗效确切；在治疗前后应常规检测患者的血脂、血流变学指标对判断冠心病严重程度及预后具有重要价值。
목적：탐토아사필림연합록필격뢰치료불은정형심교통적료효급치료전후혈지여혈액점주도적변화。방법불은정형심교통환자공120례，수궤분위량조，량조환자균급여저분자간소、아사필림등항전치료。실험조재대조조기출상가용록필격뢰치료。치료전후검측혈류변학、지질변화。통계학처리운용통계연건SPSS 19.0진행처리，소획수거채용방차분석，t검험화??2검험。결과실험조유효솔91.67%。대조조유효솔위65.00%。량조유효솔비교，P<0.005，유비상현저성차이。량조치료후24 h동태심전도대비（P<0.05）유현저성차이。혈지급혈류변학균유현저적회복P균<0.01。결론아사필림연합록필격뢰치료불은정형심교통적료효학절；재치료전후응상규검측환자적혈지、혈류변학지표대판단관심병엄중정도급예후구유중요개치。
Objective To study the joint aspirin clopidogrel treatment the curative effect and treatment of unstable angina before and after the changes of blood lipid and blood viscosity. Methods A total of 120 patients with unstable an?gina, randomly divided into two groups, two groups of patients were given low molecular heparin and aspirin antithrom?botic therapy. Based on the experimental group in the control group treated with clopidogrel. Detecting hemorrheology, lipid changes before and after treatment. Statistical processing by use of statistical software SPSS 19.0 for processing, the data obtained using analysis of variance, t test and??2 test. Results The effective rate was 91.67%. The control group ef?fective rate was 65.00%. With efficiency to compare two groups, P<0.005, there is a very significant difference. 24 h dy?namic electrocardiogram (ecg) compared the two groups after treatment (P<0.05) had significant difference. The recovery of blood lipid and hemorrheology in learning have significant P<0.01. Conclusion Combined therapy with clopidogrel aspirin curative effect is unstable angina;Should be routine tests before and after therapy in patients with blood lipid and hemorrheology indexes to judge the severity and prognosis of coronary heart disease is of important value.