CAJ | 학술논문

目的：分析我院近2年血培养阳性标本中病原菌的分布及耐药状况，为临床合理用药提供参考。方法对我院2012年1月至2013年12月送检的血培养标本检出菌的分布和药物敏感性试验结果进行回顾性分析。结果632株病原菌中，革兰阴性菌381株（60．28％），前2位是肺炎克雷伯菌105株（16．61％）、大肠埃希菌101株（15．98％）；革兰阳性菌209株（33．07％），前2位是凝固酶阴性葡萄球菌（CNS）117株（18．51％）、肠球菌40株（6．32％）；真菌42株（6．65％）；主要革兰阳性菌对万古霉素、利奈唑胺、呋喃妥因、利福平敏感，对青霉素、红霉素耐药性严重。主要革兰阴性菌对亚胺培南、头孢哌酮／舒巴坦敏感。结论 CNS为我院血液感染的主要病原菌，其耐药情况严重。分析和监测血培养病原菌分布及其耐药性，对合理使用抗菌药物具有重要指导意义。
목적：분석아원근2년혈배양양성표본중병원균적분포급내약상황，위림상합리용약제공삼고。방법대아원2012년1월지2013년12월송검적혈배양표본검출균적분포화약물민감성시험결과진행회고성분석。결과632주병원균중，혁란음성균381주（60．28％），전2위시폐염극뢰백균105주（16．61％）、대장애희균101주（15．98％）；혁란양성균209주（33．07％），전2위시응고매음성포도구균（CNS）117주（18．51％）、장구균40주（6．32％）；진균42주（6．65％）；주요혁란양성균대만고매소、리내서알、부남타인、리복평민감，대청매소、홍매소내약성엄중。주요혁란음성균대아알배남、두포고동／서파탄민감。결론 CNS위아원혈액감염적주요병원균，기내약정황엄중。분석화감측혈배양병원균분포급기내약성，대합리사용항균약물구유중요지도의의。
Objective To analyze the distribution and drug resistance of pathogens in the samples of positive blood culture in our hospital in last 2 years, so as to provide evidence for rational application of drugs clinically.Methods The distribution of detected pathogens in blood culture performed by our hospital from January, 2012 to December, 2013 and the test results of drug-sensitive tests were analyzed retrospectively.Results Of the 632 strains of pathogens, 381 strains were Gram negative bacilli, accounting for 60.28%.The first 2 pathogens were Klebsiella pneumoniae(105 strains, accounting for 16.61%) and Escherichia coli(101 strains, ac-counting for 15.98%).Two hundred and nine strains were Gram positive cocci, accounting for 33.07%.The first 2 pathogens were coagulase negative Staphylococcus ( CNS ) ( 117 strains, accounting for 18.51%) and Enterococcus ( 40 strains, accounting for 6.32%).There were 42 strains of fungi, accounting for 6.65%.Gram positive cocci displayed serious drug resistance to vancomycin, linezolid, furantoin, rifampicin, as well as penicillin and erythromycin.Main Gram negative bacilli were sensitive to imipenem and cef-operazone sulbactam.Conclusion Coagulase negative Staphylococcus ( CNS) was the main pathogen from blood culture in our hospi-tal, with serious drug resistance.Analysis and monitoring in the distribution and drug resistance of pathogens from blood culture were of guiding significance to rational application of antibacterials.