CAJ | 학술논문

五没食子酰基葡萄糖广泛存在于多种药用植物中，是具有多重药效活性的多酚化合物之一。近期研究表明：五没食子酰基葡萄糖具有缓解胰岛素抵抗、抑制α-葡萄糖苷酶及11β羟关固醇脱氢酶型、减少胰岛淀粉样多肽、糖基化终末产物的沉积，模拟胰岛素、刺激葡萄糖转运，减缓糖尿病肾病、糖尿病神经病变及血管病变等作用。五没食子酰基葡萄糖在治疗2型糖尿病及其并发症方面具有较高的价值，成为治疗糖尿病的先导化合物的候选化合物之一。
오몰식자선기포도당엄범존재우다충약용식물중，시구유다중약효활성적다분화합물지일。근기연구표명：오몰식자선기포도당구유완해이도소저항、억제α-포도당감매급11β간관고순탈경매형、감소이도정분양다태、당기화종말산물적침적，모의이도소、자격포도당전운，감완당뇨병신병、당뇨병신경병변급혈관병변등작용。오몰식자선기포도당재치료2형당뇨병급기병발증방면구유교고적개치，성위치료당뇨병적선도화합물적후선화합물지일。
Penta-O -galloyl -D -glucose is a polyphenolic compound in many kinds of medicinal plants. Resent studies have shown that penta-O-galloyl-D-glucose can improve glucose tolerance and insulin-resistance,inhibit the activity of α-glucosidase and 11-β-HSD-1,inhibit the aggregation of IAPP and advanced glycation end products,imi-tate insulin,stimulate glucose transporter,improve diabetic nephropathy,diabetic neuropathy and diabetic angiopathy. Penta-O-galloyl-D-glucose exhibits the high value of treating type 2 diabetes and complications,penta-O-galloyl-D-glucose has some conditions to be the lead compound for treating diabetes.