CAJ | 학술논문

目的：利用均匀设计法优化复方黄芩苷滴鼻凝胶基质处方。方法采用3因素10水平均匀设计方案，以复方黄芩苷滴鼻凝胶的pH值、黏度及可滴性、外观性状及粒度为评价指标，对基质处方进行优化。结果优化基质处方组成为：每100 g复方黄芩苷滴鼻凝胶含卡波姆-9400.5 g，硼砂0.75 g、磷酸盐缓冲液（ pH 6.0）10 mL。按优化处方制备的复方黄芩苷滴鼻凝胶为浅黄色透明的胶状液体，pH 6.0，黏度为2500～2800 mPa·s。结论按优化处方制备的复方黄芩苷滴鼻凝胶为淡黄色透明胶液、色泽均匀、性质稳定，使用方便。
목적：이용균균설계법우화복방황금감적비응효기질처방。방법채용3인소10수평균균설계방안，이복방황금감적비응효적pH치、점도급가적성、외관성상급립도위평개지표，대기질처방진행우화。결과우화기질처방조성위：매100 g복방황금감적비응효함잡파모-9400.5 g，붕사0.75 g、린산염완충액（ pH 6.0）10 mL。안우화처방제비적복방황금감적비응효위천황색투명적효상액체，pH 6.0，점도위2500～2800 mPa·s。결론안우화처방제비적복방황금감적비응효위담황색투명효액、색택균균、성질은정，사용방편。
OBjective TooptimizethematrixformulationofDompoundBaicalinGelNasalDropsbyuniformde-sign.Methods Thematrixformulationwasoptimizedbyathreefactorandtenleveluniformdesign,withrheologicalpa-rameterssuchaspHvalue,viscosity,fluidity,appearanceandparticlesize.Results Theoptimummatrixformulationwas established as follows:0. 5 g carbomer-940,0. 75 g borax,10 mL phosphate buffer( pH 6. 0)in 100 g Dompound Baicalin Gel Nasal Drops. The Dompound Baicalin Gel Nasal Drops was pale yellow,transparent and colloidal liquid. The pH value was6.0.Theviscositywas2500~2800mPa·s.Conclusion TheDompoundBaicalinGelNasalDropspreparedbythe method had characteristics such as good drug stability and good applicability.