药学研究
藥學研究
약학연구
JOURNAL OF PHARMACEUTICAL RESEARCH
2015年
6期
330-331
,共2页
高效液相色谱法%注射用阿扎胞苷%含量
高效液相色譜法%註射用阿扎胞苷%含量
고효액상색보법%주사용아찰포감%함량
HPLD%Azacitidine for Injection%Determination
目的:建立测定阿扎胞苷含量的高效液相色谱方法。方法采用Welch Ultimate XB-D18(4.6 mm ×250 mm,3μm)色谱柱,以0.02 mol·L-1磷酸氢二钾溶液(以磷酸溶液调pH至6.5)-甲醇(90:10)为流动相,检测波长为243 nm,柱温为(15±2)℃。结果阿扎胞苷浓度在8.16~30.6μg·mL-1浓度范围内线性良好(r=0.9999),平均回收率为98.97%,RSD为0.73%。结论本方法专属性强、准确度高,可用于阿扎胞苷的质量控制。
目的:建立測定阿扎胞苷含量的高效液相色譜方法。方法採用Welch Ultimate XB-D18(4.6 mm ×250 mm,3μm)色譜柱,以0.02 mol·L-1燐痠氫二鉀溶液(以燐痠溶液調pH至6.5)-甲醇(90:10)為流動相,檢測波長為243 nm,柱溫為(15±2)℃。結果阿扎胞苷濃度在8.16~30.6μg·mL-1濃度範圍內線性良好(r=0.9999),平均迴收率為98.97%,RSD為0.73%。結論本方法專屬性彊、準確度高,可用于阿扎胞苷的質量控製。
목적:건립측정아찰포감함량적고효액상색보방법。방법채용Welch Ultimate XB-D18(4.6 mm ×250 mm,3μm)색보주,이0.02 mol·L-1린산경이갑용액(이린산용액조pH지6.5)-갑순(90:10)위류동상,검측파장위243 nm,주온위(15±2)℃。결과아찰포감농도재8.16~30.6μg·mL-1농도범위내선성량호(r=0.9999),평균회수솔위98.97%,RSD위0.73%。결론본방법전속성강、준학도고,가용우아찰포감적질량공제。
OBjective ToestablishanHPLDmethodforthedeterminationofAzacitidine.MethodsWelchUltimate XB-D18 column(4. 6 mm × 250 mm,3μm)was used. The mobile phase consisted of 0. 02 mol·L-1 dipotassium hydrogen phosphate solution(adjust pH to 6. 5 by phosphoric acid)-methanol(90:10). The detection wavelength was 243 nm and the column temperature was(15 ± 2)℃. Results The calibration curve was linear in the range of 8. 16~30. 6 μg·mL-1 ( r=0. 999 9 ). The average recoveries was 98. 97% with corresponding RSD of 0. 73%. Conclusion The method had strong specialization and high accuracy,and can be used for the quality control of azacitidine.