CAJ | 학술논문

目的：探讨外周血单核细胞绝对计数（AMC）及淋巴细胞绝对计数（ALC）与侵袭性B细胞淋巴瘤低危患者预后的相关性。方法回顾性分析了2003～2013年42例初发侵袭性B细胞淋巴瘤低危患者的AMC、ALC及淋巴细胞／单核细胞比值（LMR）与患者各项临床指标、无进展生存期（PFS）和总生存期（OS）的相关性。结果据ROC曲线划分AMC、ALC、LMR对5年OS影响的界限值分别为475／mm3、1005／mm3和2．1。AMC≥475／mm3、ALC＜1005／mm3是 PFS的独立不良因素（RR＝4．271、3．023；P＝0．01、0．39）；AMC≥475／mm3是OS的独立不良因素（RR＝4．680；P＜0．01）。结论初发时高AMC、低ALC患者预后较差。推测外周血AMC、ALC可能成为侵袭性B细胞淋巴瘤低危患者进一步分层的预后指标。
목적：탐토외주혈단핵세포절대계수（AMC）급림파세포절대계수（ALC）여침습성B세포림파류저위환자예후적상관성。방법회고성분석료2003～2013년42례초발침습성B세포림파류저위환자적AMC、ALC급림파세포／단핵세포비치（LMR）여환자각항림상지표、무진전생존기（PFS）화총생존기（OS）적상관성。결과거ROC곡선화분AMC、ALC、LMR대5년OS영향적계한치분별위475／mm3、1005／mm3화2．1。AMC≥475／mm3、ALC＜1005／mm3시 PFS적독립불량인소（RR＝4．271、3．023；P＝0．01、0．39）；AMC≥475／mm3시OS적독립불량인소（RR＝4．680；P＜0．01）。결론초발시고AMC、저ALC환자예후교차。추측외주혈AMC、ALC가능성위침습성B세포림파류저위환자진일보분층적예후지표。
Objective To investigate the prognostic significance of peripheral blood absolute monocyte/lymphocyte count in low‐risk patients with aggressive B cell lymphoma .Methods Retrospective study was performed in 42 low‐risk patients with ag‐gressive B cell lymphoma approved by histology between 2003 to 2013 .Peripheral blood absolute monocyte count (AMC) ,absolute lymphocyte count (ALC) ,lymphocyte/monocyte(LMR) and the some other clinical characters were estimated .Results The best absolute monocyte/lymphocyte count cut‐offs respectively were 475/mm3 and 1 005/mm3 ,analyzed by receiver operating character‐istic curve .AMC≥475/mm3 and ALC<1 005/mm3 were found to be independent predictors of progress free survival (RR=4 .271 , 3 .023 ;P= 0 .01 ,0 .39);AMC≥475/mm3 was found to be independent predictors of 5‐year overall survival (RR= 4 .680;P<0 .0001) in low‐risk patients with aggressive B cell lymphoma .Conclusion Higher AMC and/or lower ALC are poor prognosis fac‐tors .AMC and ALC may be important prognostic factors of low‐risk patients with aggressive B cell lymphoma .