CAJ | 학술논문

目的：了解重庆市男男性行为（MSM）人群艾滋病患者抗病毒治疗基本情况，评估不同基线CD4＋T淋巴细胞数水平的抗病毒治疗效果。方法在国家艾滋病综合防治信息系统中收集资料，以患者开始治疗时基线CD4＋T淋巴细胞数水平分类，采用回顾性队列研究方法观察和评估治疗效果，数据运用SPSS18．0软件进行统计分析。结果1758例治疗患者平均年龄（33．5±11．1）岁，CD4＋T＜50个／μL、50～199个／μL、200～350个／μL、＞350个／μL者分别占7．7％、27．6％、54．9％、9．7％，治疗12个月后CD4＋T值分别维持在150～250个／μL、250～350个／μL、350～450个／μL、450～550个／μL，治疗6个月后病毒载量抑制比例分别为70．2％、81．7％、84．2％、83．3％，治疗36个月生存率分别为0．81、0．93、0．98、1．00。结论MSM人群艾滋病抗病毒治疗取得显著效果，早期治疗更有利于该人群免疫功能恢复，降低艾滋病病死率，控制疫情。
목적：료해중경시남남성행위（MSM）인군애자병환자항병독치료기본정황，평고불동기선CD4＋T림파세포수수평적항병독치료효과。방법재국가애자병종합방치신식계통중수집자료，이환자개시치료시기선CD4＋T림파세포수수평분류，채용회고성대렬연구방법관찰화평고치료효과，수거운용SPSS18．0연건진행통계분석。결과1758례치료환자평균년령（33．5±11．1）세，CD4＋T＜50개／μL、50～199개／μL、200～350개／μL、＞350개／μL자분별점7．7％、27．6％、54．9％、9．7％，치료12개월후CD4＋T치분별유지재150～250개／μL、250～350개／μL、350～450개／μL、450～550개／μL，치료6개월후병독재량억제비례분별위70．2％、81．7％、84．2％、83．3％，치료36개월생존솔분별위0．81、0．93、0．98、1．00。결론MSM인군애자병항병독치료취득현저효과，조기치료경유리우해인군면역공능회복，강저애자병병사솔，공제역정。
Objective To know basic characteristics of MSM infected with HIV treated by highly active antiretroviral thera‐py(HAART) ,and evaluate therapeutic effect based on the level of CD4+ T cell counts .Methods Basic database of patients were collected from the national AIDS comprehensive data information system ,patients were observed by the retrospective cohort study , and effect indicators were analyzed based on the level of CD4+ T cell counts .The data was analyzed by SPSS18 .0 software .Results A total of 1 758 cases were recruited in this study and the average age was (33 .5 ± 11 .1)years .The component ratio of the CD4+T cell counts <50/μL ,50 to 199/μL ,200 to 350/μL ,> 350/μL were 7 .7% ,27 .6% ,54 .9% ,9 .7% ,respectively .The CD4+ T counts increased and kept among 150 to 250/μL ,250 to 350/μL ,350 to 450/μL ,450 to 550/μL ,respectively after 12 months ,treat‐ment .The rates of viral inhibition were 70 .2% ,81 .7% ,84 .2% ,83 .3% ,respectively after 6 months′treatment .And the cumulative survival rates were 0 .81 ,0 .93 ,0 .98 ,1 .0 after 36 ,months treatment ,respectively .Conclusion HAART on MSM achieves remarka‐ble results .And the early treatment was more beneficial to improve immune function ,reduce AIDS mortality and control the HIV/AIDS epidemic of MSM .