CAJ | 학술논문

Grubbs催化剂是一种用于烯烃复分解反应的配位化合物,其中的配体对于催化剂的催化性能、稳定性有很大的影响. 目前,N-杂环卡宾( N-heterocyclic carbenes,NHC)是第二代Grubbs催化剂中的一个关键配体. 本文以乙二醛为原料,通过取代、还原、环化等反应,合成了一种氮杂环卡宾的前驱体1 ,3-二取代-2-羧基咪唑啉. 在此基础上,对部分关键合成环节进行了优化. 研究结果表明,在乙二醛-双-( 2 ,4 ,6三甲基苯基)亚胺的合成过程中,随着反应温度的升高,产率逐渐升高,后有所降低. 在3-( 2 ,4 ,6三甲基苯基) -2-羧基咪唑啉的合成过程中,反应时间对收率影响最大.
Grubbs최화제시일충용우희경복분해반응적배위화합물,기중적배체대우최화제적최화성능、은정성유흔대적영향. 목전,N-잡배잡빈( N-heterocyclic carbenes,NHC)시제이대Grubbs최화제중적일개관건배체. 본문이을이철위원료,통과취대、환원、배화등반응,합성료일충담잡배잡빈적전구체1 ,3-이취대-2-최기미서람. 재차기출상,대부분관건합성배절진행료우화. 연구결과표명,재을이철-쌍-( 2 ,4 ,6삼갑기분기)아알적합성과정중,수착반응온도적승고,산솔축점승고,후유소강저. 재3-( 2 ,4 ,6삼갑기분기) -2-최기미서람적합성과정중,반응시간대수솔영향최대.
Grubbs catalyst is a coordination compound for olefin metathesis. The ligand in the Grubbs' catalyst has great influence on the function and stability of the catalyst. At present, N- heterocyclic carbene ( NHC) is a key ligand for the second generation of Grubbs' catalyst. In this paper, using glyoxal as raw materials, 1,3-substituted-2- carboxy-imidazoline as pre-heterocyclic carbene was synthesized by substitution, reduction and cyclization re-actions. On this base, some key steps were optimized by reaction temperature and time.