CAJ | 학술논문

目的：观察三氧化二砷（As2O3）注射液联合化疗治疗晚期胆囊癌的近期疗效和不良反应。方法晚期胆囊癌患者41例，随机分为观察组21例，采用顺铂（GP方案）方案化疗，化疗开始时，联合As2O3注射液10mg加入5%葡萄糖溶液500ml中，静脉滴注，1次/d，持续14d。对照组20例，采用GP方案化疗。结果>2个周期疗效评价，观察组总缓解率为52.38%，其中完全缓解（CR）1例、部分缓解（PR）10例、稳定（SD）6例和进展（PD）4例。对照组总缓解率为35.00%，其中CR 1例，PR 6例，SD 5例，PD 8例。主要不良反应为消化道反应及轻度的骨髓抑制和肝功能损害。结论 As2O3注射液联合化疗治疗晚期胆囊癌有较好疗效，不良反应少。
목적：관찰삼양화이신（As2O3）주사액연합화료치료만기담낭암적근기료효화불량반응。방법만기담낭암환자41례，수궤분위관찰조21례，채용순박（GP방안）방안화료，화료개시시，연합As2O3주사액10mg가입5%포도당용액500ml중，정맥적주，1차/d，지속14d。대조조20례，채용GP방안화료。결과>2개주기료효평개，관찰조총완해솔위52.38%，기중완전완해（CR）1례、부분완해（PR）10례、은정（SD）6례화진전（PD）4례。대조조총완해솔위35.00%，기중CR 1례，PR 6례，SD 5례，PD 8례。주요불량반응위소화도반응급경도적골수억제화간공능손해。결론 As2O3주사액연합화료치료만기담낭암유교호료효，불량반응소。
Objective To evaluate the effect and toxicity of arsenic trioxide(As2O3)injection combined with chemotherapy in treating advanced gallbladder cancer.Methods Forty-one advanced gallbladder cancer patients were randomized into two groups. All received GP regimen:Gemcitabine 1000mg/m2 on days 1 and 8,and cisplatin 30mg/m2 on days 1~3.The chemotherapy was repeated every 3 weeks as one cycle.Besides,to the treatment group(21 patients),10mg As2O3 injection was adding in 500ml 5%glucose for intravenous dripping every day for 14 successive days. Results After the treatment,the objective response rate of the treatment group was 52.38%,CR 1,PR 10,SD 6,PD 4. The major side reactions were I-Ⅱ degree gastrointestinal tract reaction,mild bone marrow suppression and hepatic functional damage. The objective response rate of the compare group was 35.00%,CR 1,PR 6,SD 5,PD 8. Conclusion As2O3 injection combined with chemotherapy is effective in treating advanced gallbladder cancer with mild side reactions.