CAJ | 학술논문

目的：研究SD大鼠口服维胺酯（Via）后体内的血药浓度及组织分布情况。方法大鼠口服Via后，通过高效液相色谱检测各时间点血浆和组织中药物浓度，采用DAS2.0软件进行房室模型拟合并计算药物动力学参数。结果大鼠口服Via125 mg/kg，所得血浆药时曲线符合二室模型，主要药代动力学参数：t1/2（β）为（2.22±0.52）h；Tmax为（0.83±0.13）h；Cmax为（3.90±1.05）mg/L。Via口服后15min内可迅速分布至各主要组织器官，1 h后药物在脂肪组织浓度最高，皮肤、肌肉组织次之，骨骼最低。7 h后各组织药物浓度均明显下降。结论 Via在体内吸收迅速、清除较快、分布广泛，在脂肪和皮肤组织中浓度最高。
목적：연구SD대서구복유알지（Via）후체내적혈약농도급조직분포정황。방법대서구복Via후，통과고효액상색보검측각시간점혈장화조직중약물농도，채용DAS2.0연건진행방실모형의합병계산약물동역학삼수。결과대서구복Via125 mg/kg，소득혈장약시곡선부합이실모형，주요약대동역학삼수：t1/2（β）위（2.22±0.52）h；Tmax위（0.83±0.13）h；Cmax위（3.90±1.05）mg/L。Via구복후15min내가신속분포지각주요조직기관，1 h후약물재지방조직농도최고，피부、기육조직차지，골격최저。7 h후각조직약물농도균명현하강。결론 Via재체내흡수신속、청제교쾌、분포엄범，재지방화피부조직중농도최고。
Objective To study the plasma concentration and tissue distribution of oral viaminate in rats. Methods The plasma and tissue concentrations of viaminate were detected by high performance liquid chromatography at various times after oral administration in rats. The pharmacokinetic parameters were calculated with Das2.0 program. Results The time-concentration curve of viaminate corresponded to the model of two-compartment model after oral administration. The main pharmacokinetics parameters were:t1/2(β)=(2.22 0.52)h;Tmax=(0.83±0.13) h;Cmax=(3.90±1.05)mg/L. It was showed that viaminate was absorbed rapidly and was distributed in many tissues or organs in 15minutes.The concentration of viaminate was highest in fat at 1 h,followed by skin and muscle,lowest in skeleton. The concentrations in all of the tissues were decreased obviously. Conclusions Viaminate can be quickly absorbed and distributed in various tissues or organs in vivo, fellowed by being eliminated very quickly. The concentration of viaminate in skin and fat is higher than that in other tissues.