CAJ | 학술논문

主要针对长链非编码RNA及其与病毒的关系，尤其是长链非编码RNA在病毒致病中的功能进行了综述．长链非编码RNA（ long noncoding RNA，lncRNA）是一类广泛存在于生物体内、转录本长度超过200个核苷酸单位的非编码RNA分子，主要在表观遗传学、转录及转录后等水平上调控基因的表达．lncRNA已经被证实在多种生命现象中发挥着重要作用，包括影响细胞生长、增殖、凋亡及肿瘤发生．病毒感染普遍会引起宿主lncRNA的表达发生改变，且病毒自身编码的lncRNA同样能够调控宿主细胞基因的表达，以利于病毒的复制与感染．对于lncRNA与病毒感染关系的深入研究，必将对认识病毒－宿主相互作用及相关疾病的治疗带来新的启示．
주요침대장련비편마RNA급기여병독적관계，우기시장련비편마RNA재병독치병중적공능진행료종술．장련비편마RNA（ long noncoding RNA，lncRNA）시일류엄범존재우생물체내、전록본장도초과200개핵감산단위적비편마RNA분자，주요재표관유전학、전록급전록후등수평상조공기인적표체．lncRNA이경피증실재다충생명현상중발휘착중요작용，포괄영향세포생장、증식、조망급종류발생．병독감염보편회인기숙주lncRNA적표체발생개변，차병독자신편마적lncRNA동양능구조공숙주세포기인적표체，이리우병독적복제여감염．대우lncRNA여병독감염관계적심입연구，필장대인식병독－숙주상호작용급상관질병적치료대래신적계시．
It was summarized the recent progress in long noncoding RNA and its relationship with virus, espe-cially the function of long noncoding RNA on virus-induced oncogenesis.Long noncoding RNA ( lncRNA) was a noncoding RNA longer than 200 nucleotides, which could regulate gene expression at epigenetic, transcrip-tion and post-transcription level, and widely existed in the organism.It had been demonstrated that lncRNA play an important role in many life phenomena, which include cell proliferation, apoptosis and tumorigenesis. The role of lncRNA in the process of viral infection and carcinogenesis was summarized.The infection of virus generally would change the expression of the hosts′lncRNA.The lncRNA encoded by virus could also modu-late the expression of the hosts′gene which was critical for the infection of virus.Efforts on the researches of long noncoding RNA and its relationship with virus might give new insights into virus-host interactions and therapy of related diseases.