CAJ | 학술논문

目的：：观察半夏泻心汤加味治疗晚期食管癌的临床疗效及不良反应。方法：将晚期食管癌患者70例采用回顾性队列研究,分为在最佳支持治疗基础上联合半夏泻心汤加味治疗组和单纯最佳营养支持对照组。4周后观察进食哽咽感等的改善情况以及体力评分、生活质量(QOL)、总生存期(OS)变化情况。结果：进食哽咽/胸背痛,纳差,呕吐痰涎等方面治疗组均优于对照组，生存质量KPS治疗组提高率为82.86%，高于对照组的48.57%,生活质量QOL评分治疗组提高率为95.93%，明显高于对照组的50.33%(P＜0.05)；中位生存期治疗组为9.3月(3～26月)，对照组为5.1月(1～7月)，2组比较差异有统计学意义(P＜0.05)。结论：半夏泻心汤加味能提高晚期食管癌患者的生存质量和生存期，减轻进食哽咽感症状。
목적：：관찰반하사심탕가미치료만기식관암적림상료효급불량반응。방법：장만기식관암환자70례채용회고성대렬연구,분위재최가지지치료기출상연합반하사심탕가미치료조화단순최가영양지지대조조。4주후관찰진식경인감등적개선정황이급체력평분、생활질량(QOL)、총생존기(OS)변화정황。결과：진식경인/흉배통,납차,구토담연등방면치료조균우우대조조，생존질량KPS치료조제고솔위82.86%，고우대조조적48.57%,생활질량QOL평분치료조제고솔위95.93%，명현고우대조조적50.33%(P＜0.05)；중위생존기치료조위9.3월(3～26월)，대조조위5.1월(1～7월)，2조비교차이유통계학의의(P＜0.05)。결론：반하사심탕가미능제고만기식관암환자적생존질량화생존기，감경진식경인감증상。
Objective:To observe clinical effects and adverse reaction of modified BanXia XieXin Tang in the treatment for esophageal cancer at advanced stage. Methods:Seventy patients were divided into the treatment group of modified BanXia XieXin Tang and the control group of the best nutritional support only on the therapeutic basis of best supportive treatment by adopting retrospective cohort study. The improvement of eating choking sense, the changes of Karnofsky Performance Status (KPS), quality of life (QOL) and overall survival (OS) were observed in four weeks. Results:The treatment group was superior to the control group in eating choking sense, chest and back pain, poor appetite, vomiting phlegm and others, KPS improvement rate of the treatment group was 82.86%, higher than 48.57%of the control group, QOL scale improvement rate of the treatment group was 95.93%, significantly higher than 50.33%of the control group (P<0.05). median survival time of the treatment group was 9.3 months (3 to 26 months), longer than 5.1 months of the control group(one to seven months), the difference had statistical meaning between both groups (P<0.05). Conclusion:Modified BanXia XieXin Tang in the treatment for esophageal cancer at advanced stage could improve QOL and OS of the patients, relieve the symptoms of eating choking sense.