西部中医药
西部中醫藥
서부중의약
GANSU JOURNAL OF TRADITIONAL CHINESE MEDICINE
2015年
5期
40-42,43
,共4页
溃平宁胃内漂浮片%均匀设计%释放度%漂浮性能
潰平寧胃內漂浮片%均勻設計%釋放度%漂浮性能
궤평저위내표부편%균균설계%석방도%표부성능
KuiPingNing gastric floating tablets%homogeneous design%release rate%floatability
目的：以溃平宁提取物为模型药物，应用HPMC、十八醇、PEG、MCC为核心辅料，筛选出优化的胃内漂浮片的制备工艺，并探讨中药在胃滞留漂浮型缓控释制剂中的应用。方法：采用均匀设计法，以漂浮性能和释放度作为考察指标，对处方进行优化。结果：优化处方为溃平宁提取物∶A(混合辅料，由HPMCK-4M和HPM-CK-100M组成，各占50%)∶PEG6000∶MCC∶十八醇为100∶17∶10.12∶5∶22。结论：该制剂具有良好的漂浮性能和缓释效果。
目的：以潰平寧提取物為模型藥物，應用HPMC、十八醇、PEG、MCC為覈心輔料，篩選齣優化的胃內漂浮片的製備工藝，併探討中藥在胃滯留漂浮型緩控釋製劑中的應用。方法：採用均勻設計法，以漂浮性能和釋放度作為攷察指標，對處方進行優化。結果：優化處方為潰平寧提取物∶A(混閤輔料，由HPMCK-4M和HPM-CK-100M組成，各佔50%)∶PEG6000∶MCC∶十八醇為100∶17∶10.12∶5∶22。結論：該製劑具有良好的漂浮性能和緩釋效果。
목적：이궤평저제취물위모형약물，응용HPMC、십팔순、PEG、MCC위핵심보료，사선출우화적위내표부편적제비공예，병탐토중약재위체류표부형완공석제제중적응용。방법：채용균균설계법，이표부성능화석방도작위고찰지표，대처방진행우화。결과：우화처방위궤평저제취물∶A(혼합보료，유HPMCK-4M화HPM-CK-100M조성，각점50%)∶PEG6000∶MCC∶십팔순위100∶17∶10.12∶5∶22。결론：해제제구유량호적표부성능화완석효과。
Objective:To screen the preparation of optimum gastric floating tablets by taking KuiPingNing ex-tract as the model and HPMC, octadecanol, PEG, MCC as core materials, at the same time to discuss the application of herbs to controlled release preparation remained floating in stomach. Methods:Homogeneous design was adopted to optimize the formulation by taking floatability and release rate as the factors. Results:Optimal formulation was KuiPingNing extract:A (the mixed adjuvant materials, containing HPMCK-4M and HPMCK-100M, 50%respectively):PEG 6 000: octadecanol (100: 17: 10.12: 5: 22). Conclusion: The formulation shows good floatability and con-trolled-release effect.
