黑龙江医学
黑龍江醫學
흑룡강의학
HEILONGJIANG MEDICAL JOURNAL
2015年
6期
634-635,636
,共3页
地中海贫血%平均红细胞体积%平均红细胞血红蛋白含量%筛查
地中海貧血%平均紅細胞體積%平均紅細胞血紅蛋白含量%篩查
지중해빈혈%평균홍세포체적%평균홍세포혈홍단백함량%사사
Mediterranean anemia%Average volume of red blood cells%Average red blood cell hemoglobin content%Screening
目的:探讨平均红细胞体积( MCV)、平均红细胞血红蛋白含量( MCH)在妊娠合并轻型地中海贫血中筛查价值。方法选取2012-02~2014-03间我院产科门诊行产前检查560例孕妇为研究对象,通过检测患者红细胞计数( RBC)、血红蛋白浓度( Hb)、红细胞分布宽度( RDW)、MCV、MCH,血红蛋白电泳,筛选出贫血患者,采用地贫基因明确诊断地贫患者,根据筛查结果分成正常组(380例)、非地贫组(124例)、地贫组(56例)。对比分析三组红细胞参数,并计算MCV、MCH筛查灵敏度、特异度和诊断符合率。结果非地贫组RBC明显少于正常组和地贫组,差异有统计学意义( P<0.05),地贫组和非地贫组Hb明显少于正常组,差异有统计学意义( P<0.05),正常组RDW明显少于地贫组和非地贫组,差异有统计学意义( P<0.05),地贫组MCV、MCH值明显低于非地贫组和正常组,差异有统计学意义(P<0.05)。以地贫基因诊断结果为金标准,MCV、MCH筛查灵敏度为91.07%,特异度为90.32%,阳性符合率为91.07%。结论 MCV、MCH筛查妊娠合并轻型地中海贫血具有较高灵敏度、特异度和阳性符合率,检查简便、经济,可作为筛查妊娠合并轻型地中海贫血重要筛查手段。
目的:探討平均紅細胞體積( MCV)、平均紅細胞血紅蛋白含量( MCH)在妊娠閤併輕型地中海貧血中篩查價值。方法選取2012-02~2014-03間我院產科門診行產前檢查560例孕婦為研究對象,通過檢測患者紅細胞計數( RBC)、血紅蛋白濃度( Hb)、紅細胞分佈寬度( RDW)、MCV、MCH,血紅蛋白電泳,篩選齣貧血患者,採用地貧基因明確診斷地貧患者,根據篩查結果分成正常組(380例)、非地貧組(124例)、地貧組(56例)。對比分析三組紅細胞參數,併計算MCV、MCH篩查靈敏度、特異度和診斷符閤率。結果非地貧組RBC明顯少于正常組和地貧組,差異有統計學意義( P<0.05),地貧組和非地貧組Hb明顯少于正常組,差異有統計學意義( P<0.05),正常組RDW明顯少于地貧組和非地貧組,差異有統計學意義( P<0.05),地貧組MCV、MCH值明顯低于非地貧組和正常組,差異有統計學意義(P<0.05)。以地貧基因診斷結果為金標準,MCV、MCH篩查靈敏度為91.07%,特異度為90.32%,暘性符閤率為91.07%。結論 MCV、MCH篩查妊娠閤併輕型地中海貧血具有較高靈敏度、特異度和暘性符閤率,檢查簡便、經濟,可作為篩查妊娠閤併輕型地中海貧血重要篩查手段。
목적:탐토평균홍세포체적( MCV)、평균홍세포혈홍단백함량( MCH)재임신합병경형지중해빈혈중사사개치。방법선취2012-02~2014-03간아원산과문진행산전검사560례잉부위연구대상,통과검측환자홍세포계수( RBC)、혈홍단백농도( Hb)、홍세포분포관도( RDW)、MCV、MCH,혈홍단백전영,사선출빈혈환자,채용지빈기인명학진단지빈환자,근거사사결과분성정상조(380례)、비지빈조(124례)、지빈조(56례)。대비분석삼조홍세포삼수,병계산MCV、MCH사사령민도、특이도화진단부합솔。결과비지빈조RBC명현소우정상조화지빈조,차이유통계학의의( P<0.05),지빈조화비지빈조Hb명현소우정상조,차이유통계학의의( P<0.05),정상조RDW명현소우지빈조화비지빈조,차이유통계학의의( P<0.05),지빈조MCV、MCH치명현저우비지빈조화정상조,차이유통계학의의(P<0.05)。이지빈기인진단결과위금표준,MCV、MCH사사령민도위91.07%,특이도위90.32%,양성부합솔위91.07%。결론 MCV、MCH사사임신합병경형지중해빈혈구유교고령민도、특이도화양성부합솔,검사간편、경제,가작위사사임신합병경형지중해빈혈중요사사수단。
Objective To explore the value of average red blood cell volume (MCV), average red blood cell hemoglobin (MCH) screening pregnancy with light Mediterranean anemia .Methods Selecting 560 pregnant women from February , 2012 to March, 2014 in Maternity Department in the hospital in antenatal examination as the research object , through the detection of patients with red blood cell count (RBC), hemoglobin (Hb) concentration, red blood cell distribution width (RDW), MCV, MCH, hemoglobin electrophoresis, screening patients with anemia , and using poorest genetic to diagnose poor patients .According to the results of screening , they were divided into normal group (380 cases), not to lean group (124 cases) and poor (56 cases).Comparative analysis of three sets of red blood cell parameters was done , and screening sensitivity , specific and diagnostic coincidence rates were calculated .Results RBC not to lean group was obviously less than the normal group and poverty group , and there was statistical significance ( P<0.05 ) , and poor Hb group and not to lean group was obviously less than control group , with statistical significance ( P<0.05 ) , RDW normal group was obviously less than to the poor group and the poor with statistical significance ( P<0.05 ) , and the values of MCV , MCH lean group were obviously lower than lean group and normal group, with statistical significance (P<0.05).With poor genetic diagnosis results as the gold standard , the MCV, MCH screening sensitivity was 91.07% and 90.32%, and positive coincidence rate was 91.07%.Conclusion MCV, MCH screening pregnancy with light degree of Mediterranean anemia has high sensitivity , specific and positive coincidence rate , the check is simple and e-conomical , and can be used as screening pregnancy with important screening light Mediterranean anemia .