CAJ | 학술논문

目的:初步探讨肝龙胶囊及美洲大蠊脱脂膏对小鼠急性结肠炎的作用及可能的作用机制.方法:采用DSS造模法,通过测定小鼠的DAI并检测结肠组织的MPO含量和观察结肠组织TNF-α免疫组化表达来评价肝龙胶囊及美洲大蠊脱脂膏对急性结肠炎的影响.结果:肝龙胶囊及美洲大蠊脱脂膏能够减轻小鼠急性结肠炎的炎性因子的浸润、减少粘膜出血溃疡、降低TNF-α表达、腺体消失等现象并降低结肠组织中的MPO含量( P<0. 05).结论:肝龙胶囊及美洲大蠊脱脂膏对DSS所致的小鼠急性结肠炎有很好的保护作用.
목적:초보탐토간룡효낭급미주대렴탈지고대소서급성결장염적작용급가능적작용궤제.방법:채용DSS조모법,통과측정소서적DAI병검측결장조직적MPO함량화관찰결장조직TNF-α면역조화표체래평개간룡효낭급미주대렴탈지고대급성결장염적영향.결과:간룡효낭급미주대렴탈지고능구감경소서급성결장염적염성인자적침윤、감소점막출혈궤양、강저TNF-α표체、선체소실등현상병강저결장조직중적MPO함량( P<0. 05).결론:간룡효낭급미주대렴탈지고대DSS소치적소서급성결장염유흔호적보호작용.
Objective:To study the effect of Ganlong capsule and Periplaneta americana skim cream on acute colitis in mice and to further observe the mechanism of action. Methods:The experiment uses the DSS modeling method to evaluate the effects of Ganlong capsule and P. americana skim cream on acute colitis through the MPO content and the observation of colon tissue TNF- αimmunohistochemical and detection of mice colon tissue of calculation of DAI. Results:Ganlong capsule and P. americana skim cream can reduce infiltration of inflammatory cytokines, reduce mucosal bleeding ulcer, glands disappeared, reduce the expression of TNF-α, the Ganlong capsule groups and P. americana skim cream groups can reduce the content of MPO in the colonic tissues(P<0.05). Conclusion:Ganlong capsule and P. americana skim cream have very good protection effect on acute colitis induced by DSS.