CAJ | 학술논문

目的：观察血栓抽吸联合替罗非班在ST段抬高心肌梗死（ STEMI ）急诊直接经皮冠状动脉介入治疗（ PCI ）中的临床疗效。方法纳入40例急诊STEMI患者，根据患者治疗方案的不同将其分为两组，每组各20例。 A组进行血栓抽吸＋替罗非班冠脉内给药，B组进行血栓抽吸。观察术后两组患者ST段抬高回落百分比、血浆肌钙蛋白I（cTnI）峰值，左室舒张末内径（LVDd），左室射血分数（LVEF），B－型钠尿肽（BNP），大出血、主要心脏不良事件（MACE）发生率。结果 A组ST段抬高回落百分比、cTnI值、LVDd、LVEF、脑钠肽（ BNP）水平等均显著优于B组，差异均有显著性（ P＜0．05）。两组患者大出血以及主要心脏不良事件发生率等差异均无显著性（P＞0．05）。结论血栓抽吸＋替罗非班冠脉给药应用在STEMI急诊PCI，能够有效降低无复流的发生率，改善患者心肌灌注，改善预后，值得推广。
목적：관찰혈전추흡연합체라비반재ST단태고심기경사（ STEMI ）급진직접경피관상동맥개입치료（ PCI ）중적림상료효。방법납입40례급진STEMI환자，근거환자치료방안적불동장기분위량조，매조각20례。 A조진행혈전추흡＋체라비반관맥내급약，B조진행혈전추흡。관찰술후량조환자ST단태고회락백분비、혈장기개단백I（cTnI）봉치，좌실서장말내경（LVDd），좌실사혈분수（LVEF），B－형납뇨태（BNP），대출혈、주요심장불량사건（MACE）발생솔。결과 A조ST단태고회락백분비、cTnI치、LVDd、LVEF、뇌납태（ BNP）수평등균현저우우B조，차이균유현저성（ P＜0．05）。량조환자대출혈이급주요심장불량사건발생솔등차이균무현저성（P＞0．05）。결론혈전추흡＋체라비반관맥급약응용재STEMI급진PCI，능구유효강저무복류적발생솔，개선환자심기관주，개선예후，치득추엄。
Objective To observe the effect of thrombus aspiration combined with tirofiban in ST segment elevation myocardial infarc -tion (ST segment elevation myocardial infarction , STEMI) in emergency percutaneous coronary interventional therapy (Percutaneous coro-naryinterventions,PCI)therapy.Methods 40casesacuteSTEMIpatientswereselectedinthehospital.Accordingtothedifferenttreat-ment methods of patients , they were divided into two groups , with 20 cases in each group.A group had thrombus aspiration +tirofiban combined with intravenous administration , and B group had thrombus aspiration .The percentage of ST elevation down , peak plasma cardiac troponin I (cTnI), left ventricular end diastolic diameter (LVDd), left ventricular ejection fraction (LVEF), bleeding and major adverse cardiac event rate etc of the two groups were observed .Results ST segment elevation drop percentage , cTnI value , LVDd and LVEF in A group were significantly better than those in B group , and there was significant difference (P<0.05).There were no significant difference between major bleeding and major adverse cardiac event rate and so on of the two groups (P>0.05).Conclusion Thrombus aspiration +tirofiban intravenous combined coronary artery administration application and STEMI emergency PCI can effectively reduce the incidence of no reflow and improve myocardial perfusion and prognosis , so it is worthy of promotion.