CAJ | 학술논문

目的：研究早产小于胎龄儿（SGA）产后24 h血清中Ghrelin、胰岛素样生长因子（IGF－1）、胰岛素（INS）水平与胎龄以及发育指标的相关性。方法收集我院产科2006－10～2013－10间的出生的早产SGA500例，按照出生体重将病例分为三组：1000～1500 g的为A组（121例），1500～2000 g的为B组（245例），2000～2500 g的为C组（134例），所有的患者分别于开奶前抽取静脉血2～3 mL，离心去血清后分别测定Ghrelin、IGF－1、INS水平，研究与胎龄以及体格发育的相关性。结果早产SGA产后24 h内血清Ghrelin随着体重的增加而逐渐降低，并且经过统计学检验三组之间的差异具有统计学意义（ P＜0．05）， IGF－1、INS水平随着体重的增加逐渐升高，并且两种因素在三组之间的差异均具有统计学意义（ P＜0．05）；利用Pearson相关性分析显示，早产SGA产后24 h内血清Ghrelin水平与胎龄、出生体质量、身长、BMI呈负相关，而与出生头围相关性不明显；IGF－1水平与胎龄、出生体质量、身长、头围、BMI 呈正相关；INS水平与胎龄、出生体质量、身长、头围、BMI呈正相关。结论早产SGA产后24 h内血清Ghrelin、IGF－1、INS水平与胎龄及体格发育指标之间具有明显的相关性，同时可以将Ghrelin、IGF－1、INS水平作为婴儿体格发育的有效的指标。
목적：연구조산소우태령인（SGA）산후24 h혈청중Ghrelin、이도소양생장인자（IGF－1）、이도소（INS）수평여태령이급발육지표적상관성。방법수집아원산과2006－10～2013－10간적출생적조산SGA500례，안조출생체중장병례분위삼조：1000～1500 g적위A조（121례），1500～2000 g적위B조（245례），2000～2500 g적위C조（134례），소유적환자분별우개내전추취정맥혈2～3 mL，리심거혈청후분별측정Ghrelin、IGF－1、INS수평，연구여태령이급체격발육적상관성。결과조산SGA산후24 h내혈청Ghrelin수착체중적증가이축점강저，병차경과통계학검험삼조지간적차이구유통계학의의（ P＜0．05）， IGF－1、INS수평수착체중적증가축점승고，병차량충인소재삼조지간적차이균구유통계학의의（ P＜0．05）；이용Pearson상관성분석현시，조산SGA산후24 h내혈청Ghrelin수평여태령、출생체질량、신장、BMI정부상관，이여출생두위상관성불명현；IGF－1수평여태령、출생체질량、신장、두위、BMI 정정상관；INS수평여태령、출생체질량、신장、두위、BMI정정상관。결론조산SGA산후24 h내혈청Ghrelin、IGF－1、INS수평여태령급체격발육지표지간구유명현적상관성，동시가이장Ghrelin、IGF－1、INS수평작위영인체격발육적유효적지표。
Objective To study the relevance of the serum Ghrelin , IGF-1 and INS level with gestational age and growth indicators 24h after premature SGA.Methods Collecting 500 cases with SGA infants born from October , 2006 to October, 2013, and dividing them into three groups according to the birth weight , 1000~1500 g for group A (121 cases), 1500 ~2000 g for group B (245 cases), 2000~2500 g for group C (134 cases).All patients were extracted venous blood 2~3 mL respectively before having breast -feed, Ghrelin, IGF-1 and INS level were determined after centrifugal to serum , and the correlation of gestational age and physical development was re-searched.Results Serum Ghrelin reduced gradually with the increase of body weight 24h after premature SGA, and the difference among three groups was statistically tested , with statistical significance ( P<0.05 ) .IGF-1, INS level increased with body weight , and the differences between the two factors in three groups were statistically significant ( P<0.05 );Pearson correlation analysis showed that within 24 h after premature SGA group , serum levels of Ghrelin was negatively correlated with gestational age , birth body mass , body length and BMI, while there was no obvious correlation with birth head circumference; IGF -1 level and gestational age , birth body mass, body length, head circumference and BMI were positively correlated with INS .Conclusion The premature SGA infants within 24 h after birth and serum levels of Ghrelin , IGF 1, INS gestational age and physical development index have obvious correlation , at the same time Ghre-lin, IGF-1 and INS level can be regarded as the effective indicators of infant physical development .