化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2015年
7期
1951-1955
,共5页
壳聚糖%聚(苹果酸-co-乳酸)%聚电解质复合膜%防粘连
殼聚糖%聚(蘋果痠-co-乳痠)%聚電解質複閤膜%防粘連
각취당%취(평과산-co-유산)%취전해질복합막%방점련
chitosan%poly(lactic acid-co-malic acid)%polyelectrolyte composite film%adhesion prevention
为了克服壳聚糖薄膜力学强度差和在体液内降解太快的缺陷，首先用“一步法”合成了—COOH 含量及疏水性可控的苹果酸与乳酸共聚物（PML），再将共聚物与壳聚糖（CS）复合，通过溶液浇铸-挥发的方法制备改性复合薄膜。通过红外（FT-IR）、热重分析（TGA）、力学性能测试、降解实验及体外细胞毒性实验等方法对复合膜进行分析，研究 L-苹果酸（MA）与 D,L-乳酸（LA）的投料比（nMA∶nLA）对复合膜性能的影响。结果显示：当 nMA∶nLA 为1∶1.5时，该共聚物与 CS 的复合膜拉伸强度达到54.8MPa，断裂伸长率为10.7%，质量损失50%所需时间为28天，细胞相对增殖率为98.7%。研究表明：通过共聚物与壳聚糖之间的聚电解质相互作用，有效形成了结构均匀、性能改善的薄膜，复合膜的柔韧性提高，降解时间适当延长，性能可由共聚物的投料比来调节。复合膜无细胞毒性，生物相容性好，作为手术后防组织粘连材料具有光明的应用前景。
為瞭剋服殼聚糖薄膜力學彊度差和在體液內降解太快的缺陷，首先用“一步法”閤成瞭—COOH 含量及疏水性可控的蘋果痠與乳痠共聚物（PML），再將共聚物與殼聚糖（CS）複閤，通過溶液澆鑄-揮髮的方法製備改性複閤薄膜。通過紅外（FT-IR）、熱重分析（TGA）、力學性能測試、降解實驗及體外細胞毒性實驗等方法對複閤膜進行分析，研究 L-蘋果痠（MA）與 D,L-乳痠（LA）的投料比（nMA∶nLA）對複閤膜性能的影響。結果顯示：噹 nMA∶nLA 為1∶1.5時，該共聚物與 CS 的複閤膜拉伸彊度達到54.8MPa，斷裂伸長率為10.7%，質量損失50%所需時間為28天，細胞相對增殖率為98.7%。研究錶明：通過共聚物與殼聚糖之間的聚電解質相互作用，有效形成瞭結構均勻、性能改善的薄膜，複閤膜的柔韌性提高，降解時間適噹延長，性能可由共聚物的投料比來調節。複閤膜無細胞毒性，生物相容性好，作為手術後防組織粘連材料具有光明的應用前景。
위료극복각취당박막역학강도차화재체액내강해태쾌적결함，수선용“일보법”합성료—COOH 함량급소수성가공적평과산여유산공취물（PML），재장공취물여각취당（CS）복합，통과용액요주-휘발적방법제비개성복합박막。통과홍외（FT-IR）、열중분석（TGA）、역학성능측시、강해실험급체외세포독성실험등방법대복합막진행분석，연구 L-평과산（MA）여 D,L-유산（LA）적투료비（nMA∶nLA）대복합막성능적영향。결과현시：당 nMA∶nLA 위1∶1.5시，해공취물여 CS 적복합막랍신강도체도54.8MPa，단렬신장솔위10.7%，질량손실50%소수시간위28천，세포상대증식솔위98.7%。연구표명：통과공취물여각취당지간적취전해질상호작용，유효형성료결구균균、성능개선적박막，복합막적유인성제고，강해시간괄당연장，성능가유공취물적투료비래조절。복합막무세포독성，생물상용성호，작위수술후방조직점련재료구유광명적응용전경。
In order to overcome the drawbacks of poor mechanical strength and too fast degradation of chitosan films,poly(lactic acid-co- malic acid) (PML) was prepared by an “one-step” method,and the carboxyl content and hydrophobicity of the copolymers could be adjusted by changing the molar ratio in feed. The copolymers were added to chitosan for complexation in aqueous solutions,and the modified complex films were prepared via a casting/solvent evaporation technique. The composite films were characterized by FT-IR and TGA,and their mechanical properties,degradation and vitro cytotoxicity were investigated. The influence of molar ratio between MA and LA in feed on the structure and properties of the films were studied. The results showed that in the molar ratio of nMA∶nLA= 1∶1.5,the tensile strength of the film is 54.8MPa,breaking elongation is 10.7%,mass loss is 50% after 28 days and the 3T3 cell viability profiles are 98.7%. It is concluded that the composite film can be formed by polyelectrolyte interaction between chitosan and PML. The flexibility of the composite film is improved and degradation time is extended compared to pure chitosan film. The film properties can be adjusted by changing components in the copolymers. The composite films are non-cytotoxic,biocompatible,and have potential applications as tissue adhesion prevention materials.
