CAJ | 학술논문

目的：通过观察复方中药组分治疗链脲佐菌素制备的糖尿病模型大鼠血浆P－选择素、sICAM－1的影响，探讨中药组分治疗糖尿病微血管并发症的作用机理。方法：将链脲佐菌素制备的糖尿病模型大鼠随机分为5组，每组10只，中药组分（麦冬多糖、黄连生物碱、三七总皂苷）高、中、低剂量组[0．45、0.15、0．05g／（kg· d）]、二甲双胍组[0．05mg／（kg· d）]、模型对照组[生理盐水10ml／（kg· d）]。连续灌胃4周，采用断头采血，用酶联免疫吸附法检测血浆中P－选择素、sICAM－1的含量。结果：各组大鼠血浆中血管活性物质及细胞因子P－选择素、sICAM－1含量均低于模型对照组。结论：中药组分可能通过影响P－选择素及sICAM－1水平改善血管内皮损伤，减轻糖尿病微血管并发症。
목적：통과관찰복방중약조분치료련뇨좌균소제비적당뇨병모형대서혈장P－선택소、sICAM－1적영향，탐토중약조분치료당뇨병미혈관병발증적작용궤리。방법：장련뇨좌균소제비적당뇨병모형대서수궤분위5조，매조10지，중약조분（맥동다당、황련생물감、삼칠총조감）고、중、저제량조[0．45、0.15、0．05g／（kg· d）]、이갑쌍고조[0．05mg／（kg· d）]、모형대조조[생리염수10ml／（kg· d）]。련속관위4주，채용단두채혈，용매련면역흡부법검측혈장중P－선택소、sICAM－1적함량。결과：각조대서혈장중혈관활성물질급세포인자P－선택소、sICAM－1함량균저우모형대조조。결론：중약조분가능통과영향P－선택소급sICAM－1수평개선혈관내피손상，감경당뇨병미혈관병발증。
Objective: To observe Chinese medicine components including ophiopogonpolysaccharide, total arasaponin and rhizoma coptidis alkaloid on soluble intercellular adhesion molecule ( sICAM-1) , P-selec-tion in blood plasma of model type 2 diabetic rats induced by STZ.To explore the treatment mechanism of Chi-nese medicine components.Methods:Prepare model diabetic rats aged 8 months by high fat,high glucose feed-ing and intravenous injection of Streptozotocin( STZ) ,and those successful model rats were randomly divided into five groups, Chinese medicine component high -dose group (0.45g/kg), medium -dose group (0.15g/kg), low-dose group (0.05g/kg), metformin (0.05mg/kg) group, model group and blank control group.Each group included 10 rats which were fed with the same volume medicines respectively for consecu-tive 4 weeks.Then we collected blood by cutting heads and tested the levels of soluble intercellular adhesion molecule ( sICAM-1) , P-selection in plasma.Results: The levels of sICAM-1 and P-selection in Chi-nese medicine components groups and metformin group were lower than those in the model group.Conclusion:Chinese medicine components may contribute to microvascular complications of type 2 diabetic rats by decrea-sing the levels of sICAM-1 and P-selection, which can damage endothelial cells of blood vessels.