CAJ | 학술논문

瘦素(Leptin)是肥胖基因(Obesegene)的产物,属于I型细胞因子.在哺乳动物中, leptin主要由脂肪细胞合成与分泌, 是调控摄食、能量代谢、骨骼发育、甲状腺功能以及繁殖等生理过程的重要激素.目前, 多种硬骨鱼类的 leptin 基因已被克隆, 其功能也已得到初步研究.研究认为, 鱼类 leptin的主要合成部位在肝脏,其在氨基酸序列上与哺乳动物存在很大差异,但蛋白质结构高度保守;功能方面, leptin可调节鱼类的摄食、葡萄糖和脂肪代谢以及繁殖等生命活动过程.本文就鱼类leptin及其受体的特征结构、组织分布、表达调控及功能研究进展进行简要综述.
수소(Leptin)시비반기인(Obesegene)적산물,속우I형세포인자.재포유동물중, leptin주요유지방세포합성여분비, 시조공섭식、능량대사、골격발육、갑상선공능이급번식등생리과정적중요격소.목전, 다충경골어류적 leptin 기인이피극륭, 기공능야이득도초보연구.연구인위, 어류 leptin적주요합성부위재간장,기재안기산서렬상여포유동물존재흔대차이,단단백질결구고도보수;공능방면, leptin가조절어류적섭식、포도당화지방대사이급번식등생명활동과정.본문취어류leptin급기수체적특정결구、조직분포、표체조공급공능연구진전진행간요종술.
Leptin is the product ofob gene and a kind of Type I cytokine. It is primarily synthesized and secreted by adipocytes and plays an important role in the regulation of ingestion, energy metabolism, skeletal development, thyroid function, and reproduction in mammals. To dateleptin gene has been cloned in various teleostean groups, and there have been studies of the physiological functions of leptin. Previous reports have suggested that fish leptin is mainly synthe-sized in liver, and the amino acid sequence is different from that in mammals; however, the protein structure is highly conservative. Because of its crucial roles in ingestion, glucose and lipid metabolism, and reproduction, Leptin is poten-tially a new drug target for improving the glucose utilization efficiency in fish in the future. Therefore in this review we discussed about fish leptin in terms of its structure, expression, functions, tissue-specific distribution and receptors.