中国中西医结合外科杂志
中國中西醫結閤外科雜誌
중국중서의결합외과잡지
CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2015年
3期
218-220
,共3页
黄敏%卢根林%斯伟宏%吴爱兵
黃敏%盧根林%斯偉宏%吳愛兵
황민%로근림%사위굉%오애병
急性胰腺炎%硫化氢%血液流变学
急性胰腺炎%硫化氫%血液流變學
급성이선염%류화경%혈액류변학
Acute pancreatitis%hydrogen sulfide%haemorheology
目的：研究硫化氢（H2S）对急性胰腺炎患者血液流变学的影响。方法：选取重症急性胰腺炎患者（A组）、轻型急性胰腺炎患者（B组）和健康对照者（C组）各40例，留取静脉血测定H2S、血液流变学指标、单核细胞蛋白酶激活受体-1(PAR-1)、组织因子(TF)等含量变化，藉此评价H2S对急性胰腺炎患者血液流变学的影响。结果：A组红细胞聚集指数、血沉、血浆黏度、全血高切黏度、全血低切黏度等均显著高于B组、C组，B组显著高于C组（P＜0.01）；A组H2S、PAR-1、TF分别为（42.57±7.18）μmol/L、38.53±9.84、（344.24±28.47）ng/L，也分别高于B组的（35.27±3.14）μmol/L、23.42±5.16、（271.67±31.45）ng/L、C组的（24.38±2.69）μmol/L、4.53±2.12、（5.63±3.24）ng/L，B组的这3个指标值分别高于C组的值（P＜0.01）。H2S与红细胞聚集指数、血沉、血浆黏度、全血高切黏度、全血低切黏度、PAR-1、TF呈正相关（r分别为0.87、0.74、0.81、0.67、0.78、0.87、0.86, P＜0.01）。结论：内源性H2S是一种炎症介质，上调TF、PAR-1表达，引起急性胰腺炎患者血液流变学指标异常。
目的：研究硫化氫（H2S）對急性胰腺炎患者血液流變學的影響。方法：選取重癥急性胰腺炎患者（A組）、輕型急性胰腺炎患者（B組）和健康對照者（C組）各40例，留取靜脈血測定H2S、血液流變學指標、單覈細胞蛋白酶激活受體-1(PAR-1)、組織因子(TF)等含量變化，藉此評價H2S對急性胰腺炎患者血液流變學的影響。結果：A組紅細胞聚集指數、血沉、血漿黏度、全血高切黏度、全血低切黏度等均顯著高于B組、C組，B組顯著高于C組（P＜0.01）；A組H2S、PAR-1、TF分彆為（42.57±7.18）μmol/L、38.53±9.84、（344.24±28.47）ng/L，也分彆高于B組的（35.27±3.14）μmol/L、23.42±5.16、（271.67±31.45）ng/L、C組的（24.38±2.69）μmol/L、4.53±2.12、（5.63±3.24）ng/L，B組的這3箇指標值分彆高于C組的值（P＜0.01）。H2S與紅細胞聚集指數、血沉、血漿黏度、全血高切黏度、全血低切黏度、PAR-1、TF呈正相關（r分彆為0.87、0.74、0.81、0.67、0.78、0.87、0.86, P＜0.01）。結論：內源性H2S是一種炎癥介質，上調TF、PAR-1錶達，引起急性胰腺炎患者血液流變學指標異常。
목적：연구류화경（H2S）대급성이선염환자혈액류변학적영향。방법：선취중증급성이선염환자（A조）、경형급성이선염환자（B조）화건강대조자（C조）각40례，류취정맥혈측정H2S、혈액류변학지표、단핵세포단백매격활수체-1(PAR-1)、조직인자(TF)등함량변화，자차평개H2S대급성이선염환자혈액류변학적영향。결과：A조홍세포취집지수、혈침、혈장점도、전혈고절점도、전혈저절점도등균현저고우B조、C조，B조현저고우C조（P＜0.01）；A조H2S、PAR-1、TF분별위（42.57±7.18）μmol/L、38.53±9.84、（344.24±28.47）ng/L，야분별고우B조적（35.27±3.14）μmol/L、23.42±5.16、（271.67±31.45）ng/L、C조적（24.38±2.69）μmol/L、4.53±2.12、（5.63±3.24）ng/L，B조적저3개지표치분별고우C조적치（P＜0.01）。H2S여홍세포취집지수、혈침、혈장점도、전혈고절점도、전혈저절점도、PAR-1、TF정정상관（r분별위0.87、0.74、0.81、0.67、0.78、0.87、0.86, P＜0.01）。결론：내원성H2S시일충염증개질，상조TF、PAR-1표체，인기급성이선염환자혈액류변학지표이상。
Objective To study the influence of hydrogen sulfide on haemorheology parameter in patients with acute pancreatitis. Methods Forty patients suffered from severe acute pancreatitis were selected as group A, 40 patients subjected to mild acute pancreatitis were distributed to group B. Healthy persons were in?cluded in control group. Blood was used to detect hydrogen sulfide, haemorheology parameter, protease activated receptor-l (PAR-1)of monocytes, tissue factor (TF)in order to investigate he influence of hydrogen sulfide on pa?tients' haemorheology parameter with acute pancreatitis.. Results Erythrocyte aggregation index, ESR, plasma viscosity, high blood viscosity, low blood viscosity in patients with severe acute pancreatitis, was significantly higher than that in patients of group B and C. Also, these parameters in group B were predominantly higher than in group C(P<0.01). H2S, PAR-1,TF in patients of group A were(42.57±7.18)μmol/L,38.53±9.84,(344.24± 28.47)ng/L respectively. In group B, they were(35.27±3.14)μmol/L,23.42±5.16 and(271.67±31.45)ng/L re?spectively. In group C, these values were (24.38 ± 2.69)μmol/L,4.53 ± 2.12,(5.63 ± 3.24) ng/L. The three values in group A were obviously higher than those in group B and C. H2S positively correlated with erythrocyte aggre?gation index, ESR, plasma viscosity,high blood viscosity, low blood viscosity, PAR-1, TF(r= 0.87,0.74,0.81,0.67, 0.78,0.87,0.86, respectively). Conclusion Endoge?nous H2S, as a inflammatory factor, up-regulates PAR-1 and TF which makes haemorheology parame?ter abnormal in patients with acute pancreatitis .
