CAJ | 학술논문

目的：探讨深静脉血栓形成（DVT）不同中医证型与黏附因子的关系。方法：将70例DVT患者按中医辨证分为湿热下注组（A组）、血瘀湿重组（B组），并设正常对照组（C组）30例，检测各组细胞间黏附因子-1（ICAM-1）、P-选择素和E-选择素的水平。结果：ICAM-1在湿热下注组、血瘀湿重组及正常对照组水平分别是（194.746±18.237） ng/mL、（206.742±23.361）ng/mL、（160.435±23.410）ng/mL，DVT各组ICAM-1水平显著高于正常对照组（P＜0.01），血瘀湿重组ICAM-1水平高于湿热下注组（P＜0.01）；P-选择素在3组水平是（54.093±6.606）ng/mL、（49.889±7.363）ng/mL、（31.166±6.945）ng/mL，依次降低（P＜0.05，P＜0.01）；E-选择素在3组的表达水平分别为（64.125±8.482）ng/mL、（30.975±8.723）ng/mL、（27.465±4.934）ng/mL，湿热下注组高于血瘀湿重组及正常对照组（P＜0.01，P＜0.05），但血瘀湿重组与正常对照组相比无明显差异（P＞0.05）。结论：黏附因子与深静脉血栓形成的中医证型之间存在一定的关系，而ICAM-1、P-选择素和E-选择素的水平高低可协助中医辨证。
목적：탐토심정맥혈전형성（DVT）불동중의증형여점부인자적관계。방법：장70례DVT환자안중의변증분위습열하주조（A조）、혈어습중조（B조），병설정상대조조（C조）30례，검측각조세포간점부인자-1（ICAM-1）、P-선택소화E-선택소적수평。결과：ICAM-1재습열하주조、혈어습중조급정상대조조수평분별시（194.746±18.237） ng/mL、（206.742±23.361）ng/mL、（160.435±23.410）ng/mL，DVT각조ICAM-1수평현저고우정상대조조（P＜0.01），혈어습중조ICAM-1수평고우습열하주조（P＜0.01）；P-선택소재3조수평시（54.093±6.606）ng/mL、（49.889±7.363）ng/mL、（31.166±6.945）ng/mL，의차강저（P＜0.05，P＜0.01）；E-선택소재3조적표체수평분별위（64.125±8.482）ng/mL、（30.975±8.723）ng/mL、（27.465±4.934）ng/mL，습열하주조고우혈어습중조급정상대조조（P＜0.01，P＜0.05），단혈어습중조여정상대조조상비무명현차이（P＞0.05）。결론：점부인자여심정맥혈전형성적중의증형지간존재일정적관계，이ICAM-1、P-선택소화E-선택소적수평고저가협조중의변증。
Objective To explore the relationship between deep vein thrombosis(DVT) in different syn?dromes of Traditional Chinese Medicine(TCM) and cell adhesion molecules. Methods Based on the syn?drome differentiation type of TCM, 70 patients with DVT were divided into the syndrome of pathogenic damp?ness-heat(A), the syndrome of blood stasis and dampness(B), and 30 healthy people were taken as control. All patients and healthy persons were detected blood serum levels of ICAM-1, P-selectin, E-selectin by immunotur?bidimetry. Results The detection of ICAM-1 in A, B and C groups showed respectively:(194.746 ± 18.237) ng/mL, (206.742 ± 23.361) ng/mL, and (160.435 ± 23.410) ng/mL, The DVT levels in patients with ICAM-1 in A and B groups were higher than that in group C(P<0.01), the ICAM-1 level of group B was higher than that in group A (P<0.01). P-selectin in group A, group B and group C expression level showed:(54.093 ± 6.606) ng/mL, (49.889 ± 7.363) ng/mL, and (31.166 ± 6.945) ng/mL, in the order of decreasing, with signifi?cant differences(P<0.05, P<0.01). While the E-selectin expression levels in the three groups were:(64.125 ± 8.482) ng/mL, (30.975 ± 8.723) ng/mL, and (27.465 ± 4.934) ng/mL, group A was higher than those in group B and group C (P<0.01, P<0.05), but no significant difference compared with B group and C group (P>0.05). Conclusion There is a certain relationship between cell adhesion molecules and TCM syndrome type of deep venous thrombosis and the level of ICAM-1, P- selectin and E-selectin can help TCM syndrome differentiation .