中国中西医结合外科杂志
中國中西醫結閤外科雜誌
중국중서의결합외과잡지
CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2015年
3期
221-223
,共3页
前列腺癌%Livin%组织芯片%免疫组织化学
前列腺癌%Livin%組織芯片%免疫組織化學
전렬선암%Livin%조직심편%면역조직화학
Prostate cancer%livin%tissue microarray%immunohistochemistry
目的：检测凋亡抑制蛋白Livin在前列腺癌中的表达及其与临床病理特征的关系。方法：采用组织芯片技术构建71例前列腺癌和37例前列腺增生组织的64点阵石蜡组织芯片，用免疫组化 SP 法检测该芯片中凋亡抑制蛋白Livin的表达，分析其与前列腺癌临床病理特征的关系。结果：凋亡抑制蛋白Livin在前列腺癌组织中的阳性表达率为60.94%，在前列腺增生组织中阳性表达率为2.70%(P＜0.01)。Livin表达与前列腺癌Gleason评分和临床分期有关，Livin在Gleason＜7分的阳性表达率为41.67%，Livin在≥7分的表达率为85.71%，在前列腺癌Ⅰ~Ⅱ期和Ⅲ~Ⅳ期阳性表达率分别为53.66%和82.61%(P＜0.05)。结论：凋亡抑制蛋白Livin表达与前列腺癌的发生进展关系密切。
目的：檢測凋亡抑製蛋白Livin在前列腺癌中的錶達及其與臨床病理特徵的關繫。方法：採用組織芯片技術構建71例前列腺癌和37例前列腺增生組織的64點陣石蠟組織芯片，用免疫組化 SP 法檢測該芯片中凋亡抑製蛋白Livin的錶達，分析其與前列腺癌臨床病理特徵的關繫。結果：凋亡抑製蛋白Livin在前列腺癌組織中的暘性錶達率為60.94%，在前列腺增生組織中暘性錶達率為2.70%(P＜0.01)。Livin錶達與前列腺癌Gleason評分和臨床分期有關，Livin在Gleason＜7分的暘性錶達率為41.67%，Livin在≥7分的錶達率為85.71%，在前列腺癌Ⅰ~Ⅱ期和Ⅲ~Ⅳ期暘性錶達率分彆為53.66%和82.61%(P＜0.05)。結論：凋亡抑製蛋白Livin錶達與前列腺癌的髮生進展關繫密切。
목적：검측조망억제단백Livin재전렬선암중적표체급기여림상병리특정적관계。방법：채용조직심편기술구건71례전렬선암화37례전렬선증생조직적64점진석사조직심편，용면역조화 SP 법검측해심편중조망억제단백Livin적표체，분석기여전렬선암림상병리특정적관계。결과：조망억제단백Livin재전렬선암조직중적양성표체솔위60.94%，재전렬선증생조직중양성표체솔위2.70%(P＜0.01)。Livin표체여전렬선암Gleason평분화림상분기유관，Livin재Gleason＜7분적양성표체솔위41.67%，Livin재≥7분적표체솔위85.71%，재전렬선암Ⅰ~Ⅱ기화Ⅲ~Ⅳ기양성표체솔분별위53.66%화82.61%(P＜0.05)。결론：조망억제단백Livin표체여전렬선암적발생진전관계밀절。
Objective To detect expression of Apoptosis Inhibitor Protein Livin and clinical pathological characteristics of patients with prostate cancer. Methods Tissue microarray technology was performed in 71 cases of prostate cancer tissues and 37 cases of benign prostatic hyperplasia, microarray and immunohistochemi?cal method were used to detect expression of Apoptosis Inhibitor Protein Livin in the chip. An important relation?ship was found between the expression of Apoptosis Inhibitor Protein Livin, Gleason score and the clinical stag?es of prostate cancer. Results In patients with prostate cancer, Livin positive expression rate was 60.94%, In hyperplasia tissue the expression rate was 2.70%, There was a significant difference (P<0.01). Positive expres?sion rate of Livin in Gleason score <7 was 41.67% , the rate of Livin expression in Gleason score≥7 was 85.71%. The positive expression rates in Ⅰ~Ⅱ and Ⅲ~Ⅳ stages of prostate cancer were respectively 53.66%and 82.61%, and were significantly different (P<0.05). Livin expression in prostate cancer was significantly re?lated to Gleason score and clinical stage (P<0.05). Conclusion Abnormal expression of apoptosis inhibition protein Livin is closely related to the development of prostate cancer.
