癫癎与神经电生理学杂志
癲癎與神經電生理學雜誌
전간여신경전생이학잡지
JOURNAL OF EPILEPTOLOGY AND ELECTRONEUROPHYSIOLOGY(CHINA)
2015年
3期
151-155
,共5页
癫%左乙拉西坦(LEV)%疗效%安全性%预后
癲%左乙拉西坦(LEV)%療效%安全性%預後
전%좌을랍서탄(LEV)%료효%안전성%예후
adult%levetiracetam (LEV)%epilepsy%efficacy%safety%prognosis
目的：观察左乙拉西坦（LEV）单药和（或）添加治疗成人癫?的临床治疗效果及安全性，旨在为今后临床治疗方案的选择提供参考和借鉴。方法：前瞻性选取本院神经内科2010～2013年4年间收治的160例成人癫?患者，根据是否为新确诊患者分为2组：Ⅰ组为既往确诊患者给予LEV添加治疗，Ⅱ组为新诊断癫?患者开始即给予L EV单药治疗，对比两组患者临床疗效及不良反应。结果：Ⅰ组总有效率为85．8％，略低于Ⅱ组的87．5％，但差异无统计学意义（χ2＝0．0703，P＝0．7909）；各型癫?疗效比较差异亦无统计学意义（ P＞0．05）；Ⅰ组脑电图缓解率为48．1％，略低于Ⅱ组的53．3％（χ2＝0．1287，P＝0．7198），均无1例脑电图加重；Ⅰ组不良反应发生率为29．2％略高于Ⅱ组的27．5％（χ2＝0．0407，P＝0．8402），副作用均较轻微，未给予处理，于2～5周内缓解或消失。结论：L EV不管是单药还是添加治疗对各型成人癫?具有疗效，能显著改善患者脑电图，不良反应发生率低且症状轻微，持续时间短，患者耐受性好，可作为临床治疗成人癫?的首选药物之一。
目的：觀察左乙拉西坦（LEV）單藥和（或）添加治療成人癲?的臨床治療效果及安全性，旨在為今後臨床治療方案的選擇提供參攷和藉鑒。方法：前瞻性選取本院神經內科2010～2013年4年間收治的160例成人癲?患者，根據是否為新確診患者分為2組：Ⅰ組為既往確診患者給予LEV添加治療，Ⅱ組為新診斷癲?患者開始即給予L EV單藥治療，對比兩組患者臨床療效及不良反應。結果：Ⅰ組總有效率為85．8％，略低于Ⅱ組的87．5％，但差異無統計學意義（χ2＝0．0703，P＝0．7909）；各型癲?療效比較差異亦無統計學意義（ P＞0．05）；Ⅰ組腦電圖緩解率為48．1％，略低于Ⅱ組的53．3％（χ2＝0．1287，P＝0．7198），均無1例腦電圖加重；Ⅰ組不良反應髮生率為29．2％略高于Ⅱ組的27．5％（χ2＝0．0407，P＝0．8402），副作用均較輕微，未給予處理，于2～5週內緩解或消失。結論：L EV不管是單藥還是添加治療對各型成人癲?具有療效，能顯著改善患者腦電圖，不良反應髮生率低且癥狀輕微，持續時間短，患者耐受性好，可作為臨床治療成人癲?的首選藥物之一。
목적：관찰좌을랍서탄（LEV）단약화（혹）첨가치료성인전?적림상치료효과급안전성，지재위금후림상치료방안적선택제공삼고화차감。방법：전첨성선취본원신경내과2010～2013년4년간수치적160례성인전?환자，근거시부위신학진환자분위2조：Ⅰ조위기왕학진환자급여LEV첨가치료，Ⅱ조위신진단전?환자개시즉급여L EV단약치료，대비량조환자림상료효급불량반응。결과：Ⅰ조총유효솔위85．8％，략저우Ⅱ조적87．5％，단차이무통계학의의（χ2＝0．0703，P＝0．7909）；각형전?료효비교차이역무통계학의의（ P＞0．05）；Ⅰ조뇌전도완해솔위48．1％，략저우Ⅱ조적53．3％（χ2＝0．1287，P＝0．7198），균무1례뇌전도가중；Ⅰ조불량반응발생솔위29．2％략고우Ⅱ조적27．5％（χ2＝0．0407，P＝0．8402），부작용균교경미，미급여처리，우2～5주내완해혹소실。결론：L EV불관시단약환시첨가치료대각형성인전?구유료효，능현저개선환자뇌전도，불량반응발생솔저차증상경미，지속시간단，환자내수성호，가작위림상치료성인전?적수선약물지일。
Objective:To observe the effect and safety of levetiracetam (LEV) monotherapy or /and add‐on therapy in adults with epilepsy ,aiming at providing reference for further clinical treatment .Meth‐ods:160 adult patients with epilepsy were selected in our hospital from 2010 to 2013 and divided into 2 groups according to whether newly diagnosed patients .Group I as previously diagnosed patients were giv‐en add‐on LEV therapy ,and Group Ⅱ as monotherapy given LEV in newly diagnosed epileptic patients , comparative analysis and the incidence of adverse reactions of two groups with clinical curative effect .Re‐sults:Total effective rate of Group I was 85 .83% ,slightly lower than that in Group Ⅱ (87 .5% ,χ2 =0 .0703 ,P=0 .7909);Each type of epilepsy showed no statistical significance (P>0 .05);In Group I EEG response rate(48 .1% )was rate slightly lower than that in Group Ⅱ (53 .3% ,χ2 =0 .1287 ,P=0 .7198);There were no werse EEG in patients ;good reaction rate in Group Ⅰ rate(29 .2% )was slightly higher than that of Group Ⅱ(27 .5% ,χ2 =0 .0407 ,P=0 .8402) ,the side‐effect was minor and its symptom re‐lieved or disappeared within 2~5 weeks .Conclusion:LEV monotherapy or its add‐on therapy is effective in the treatment of epilepsy in adults .It can significantly improve patients EEG .The patient has low inci‐dence of adverse reactions .The symptoms are mild and of short duration ,the patient’s tolerance is fine .It can be used as one of the best drugs in clinical treatment of adults with epilepsy .
