CAJ | 학술논문

以Triton X-100六角相溶致液晶作微反应器,采用共沉淀法制备了镁铝层状双金属氢氧化物(LDHs)纳米薄片(L-LDHs).以双氯芬酸钠(DS)为药物模型分子,采用离子交换法制备了DS插层LDHs (DS/L-LDHs)纳米杂化物,在37.0°C、pH=7.2的缓冲溶液中,考察了纳米杂化物的药物释放性能,并与传统溶液共沉淀法制备的镁铝LDHs (S-LDHs)纳米片状颗粒进行了对比.采用粉末X射线衍射(XRD)、傅里叶变换红外(FT-IR)光谱、场发射扫描电镜(FE-SEM)、透射电镜(TEM)和N2吸附-脱附等技术对所制备的LDHs和DS/LDHs样品的晶体结构、比表面积、形貌特征等进行了表征.结果表明, L-LDHs比S-LDHs具有更低的片厚度,更高的比表面积和药物负载量,所形成的DS/L-LDHs纳米杂化物药物释放速率也明显低于DS/S-LSHs,即L-LDHs更适于作药物载体. DS/L-LDHs纳米杂化物的药物释放过程符合准二级动力学方程,受颗粒内部扩散过程控制.溶致液晶模板法可实现LDHs的形貌可控制备,为LDHs基功能材料的研发提供了新途径.
이Triton X-100륙각상용치액정작미반응기,채용공침정법제비료미려층상쌍금속경양화물(LDHs)납미박편(L-LDHs).이쌍록분산납(DS)위약물모형분자,채용리자교환법제비료DS삽층LDHs (DS/L-LDHs)납미잡화물,재37.0°C、pH=7.2적완충용액중,고찰료납미잡화물적약물석방성능,병여전통용액공침정법제비적미려LDHs (S-LDHs)납미편상과립진행료대비.채용분말X사선연사(XRD)、부리협변환홍외(FT-IR)광보、장발사소묘전경(FE-SEM)、투사전경(TEM)화N2흡부-탈부등기술대소제비적LDHs화DS/LDHs양품적정체결구、비표면적、형모특정등진행료표정.결과표명, L-LDHs비S-LDHs구유경저적편후도,경고적비표면적화약물부재량,소형성적DS/L-LDHs납미잡화물약물석방속솔야명현저우DS/S-LSHs,즉L-LDHs경괄우작약물재체. DS/L-LDHs납미잡화물적약물석방과정부합준이급동역학방정,수과립내부확산과정공제.용치액정모판법가실현LDHs적형모가공제비,위LDHs기공능재료적연발제공료신도경.
A hexagonal lyotropic liquid crystal (LLC) was constructed with nonionic surfactant Triton X-100 and mixed magnesium chloride/aluminum chloride aqueous solutions. Layered double hydroxide (LDH) nanosheets (L-LDHs) were prepared using the LLC as a microreactor. A nanohybrid material of L-LDHs intercalated with a model anionic drug, diclofenac sodium (DS;DS/L-LDHs) was synthesized using an ion-exchange method. The drug-release profile of DS/L-LDH was investigated under moderate conditions, i.e., 37.0 °C and pH 7.2. The results were compared with those for common LDH flaky particles (S-LDHs) synthesized using a traditional solution coprecipitation method. The crystal ine structures, specific surface areas, and morphologies of these LDHs and DS/LDHs nanohybrids were characterized using powder X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and N2 adsorption-desorption. The results show that the L-LDH particles are less thick, and have larger specific surface areas and higher DS-loading capacities than the S-LDH particles. Drug release by the DS/L-LDH nanohybrid was clearly lower than that by the DS/S-LDH nanohybrid. This indicates that the L-LDH nanosheets are more suitable for use as drug carriers than the S-LDHs. Drug release by the DS/L-LDH nanohybrid can be described using a pesudo-second-order kinetic model, and drug diffusion through the LDH particles is the rate-limiting step. LLC can be used as a template for morphology-control ed synthesis of LDHs.