CAJ | 학술논문

目的：研究酸蚀喷砂（SLA）处理的微螺钉种植体骨界面的组织形态学变化情况。方法选择6只成年Beagle犬，将36个微螺钉种植体，随机分为2组，SLA组（n=18），对照组（n=18）。在下颌骨左右侧各选择3个植入部位，在实验开始、实验4周、实验6周不同时间点，于下颌骨左右侧植入SLA种植体及未处理种植体各1枚，实验8周时处死6只实验动物，获得愈合2周、4周、8周的骨组织标本，苏木精-伊红（HE）染色观察种植体骨界面组织学变化。结果 SLA组2周时，镜下可见破骨细胞和骨陷窝，成骨细胞表现活跃并伴许多新生骨的出现；对照组可见成骨细胞比较少，纤维组织比较多并紊乱排列。4周时，对照组显示新生骨增多，但成骨细胞不规则排列；SLA组可见成骨细胞进行有序的排列，骨小梁增多，骨质成熟。SLA组与对照组8周时，均可见骨小梁交织连接，呈现致密骨基质。结论微种植体表面进行SLA处理后，植入初期可促进微种植体骨界面成骨细胞的形成，利于提高微种植体骨整合率。
목적：연구산식분사（SLA）처리적미라정충식체골계면적조직형태학변화정황。방법선택6지성년Beagle견，장36개미라정충식체，수궤분위2조，SLA조（n=18），대조조（n=18）。재하합골좌우측각선택3개식입부위，재실험개시、실험4주、실험6주불동시간점，우하합골좌우측식입SLA충식체급미처리충식체각1매，실험8주시처사6지실험동물，획득유합2주、4주、8주적골조직표본，소목정-이홍（HE）염색관찰충식체골계면조직학변화。결과 SLA조2주시，경하가견파골세포화골함와，성골세포표현활약병반허다신생골적출현；대조조가견성골세포비교소，섬유조직비교다병문란배렬。4주시，대조조현시신생골증다，단성골세포불규칙배렬；SLA조가견성골세포진행유서적배렬，골소량증다，골질성숙。SLA조여대조조8주시，균가견골소량교직련접，정현치밀골기질。결론미충식체표면진행SLA처리후，식입초기가촉진미충식체골계면성골세포적형성，리우제고미충식체골정합솔。
Objective To investigate the histomorphological change in bone surface of sandblasted, large-grit, and acid-etched (SLA) microscrew implant. Methods Six adult Beagle dogs were included in the study. A total of 36 microscrew implants were randomly divided into two groups, the SLA group and the control group (n=18 each). Three implant positions were selected at each of the left and right sides of the mandible, respectively. At the different time points (baseline, 4 weeks and 6 weeks of the experiment), one SLA implant and untreated implant were implant-ed each at the left and right sides of the mandible, respectively. Six experimental animals were executed at 8 weeks of the experiment. The bone tissue samples at 2, 4 and 8 weeks of the experiment were obtained. The histological changes of the bone surfaces of the implants were observed by HE staining. Results At 2 weeks, the SLA group ex-hibited osteoclasts, bone lacuna, and active osteoblasting with massive new bone formation as found under microscope, compared with few osteoblasts and lots of deranged fibrous tissues in the control group. At 4 weeks, the control group showed increased new bones and disarrayed osteoblasts, compared with regularly arranged osteoblasts, increased bone trabecula and mature bones found in the SLA group. Connected bone trabeculae with high density bone matrix were found in both the SLA group and the control group at 8 weeks. Conclusion The formation of osteoblasts at the bone surface of SLA microscrew implant can be promoted early during implantation period, which favors the increase of os-seointegration rate of microscrew implant.