CAJ | 학술논문

目的：研究自身免疫病患者血清25-羟维生素D[25（OH）D]水平，并探讨其临床意义。方法收集资料完整的91例自身免疫病患者，回顾性分析血清25（OH）D水平、骨密度，及相关临床资料，包括原发病、发病年龄、性别、吸烟、饮酒、病程、BMI指数、ESR、CRP等，相关性采用Pearson相关分析。结果血清25（OH）D水平与ESR呈负相关（r=-0.273，P<0.01），与性别呈负相关（r=-0.330，P<0.01）；骨密度与年龄呈负相关（r=-0.433， P<0.01）；RA患者血清25（OH）D水平与年龄呈负相关（r=-0.781，P<0.01），与BMI指数呈负相关（r=-0.681，P<0.01）；SpA患者骨密度与年龄呈负相关（r=-0.517，P<0.01），与病程呈负相关（r=-0.381，P<0.05）。结论自身免疫病患者的血清25（OH）D水平及骨密度与部分临床指标具有明显相关性，提示适量补充维生素D对延缓疾病的发生发展具有一定指导意义，积极治疗有助于改善预后。
목적：연구자신면역병환자혈청25-간유생소D[25（OH）D]수평，병탐토기림상의의。방법수집자료완정적91례자신면역병환자，회고성분석혈청25（OH）D수평、골밀도，급상관림상자료，포괄원발병、발병년령、성별、흡연、음주、병정、BMI지수、ESR、CRP등，상관성채용Pearson상관분석。결과혈청25（OH）D수평여ESR정부상관（r=-0.273，P<0.01），여성별정부상관（r=-0.330，P<0.01）；골밀도여년령정부상관（r=-0.433， P<0.01）；RA환자혈청25（OH）D수평여년령정부상관（r=-0.781，P<0.01），여BMI지수정부상관（r=-0.681，P<0.01）；SpA환자골밀도여년령정부상관（r=-0.517，P<0.01），여병정정부상관（r=-0.381，P<0.05）。결론자신면역병환자적혈청25（OH）D수평급골밀도여부분림상지표구유명현상관성，제시괄량보충유생소D대연완질병적발생발전구유일정지도의의，적겁치료유조우개선예후。
Objective To investigate the level and clinical significance of 25-hydroxyl vitamin D [25 (OH) D) in patients with autoimmune diseases (AID). Methods The complete data of 91 AID cases were retrieved. The serum level of 25 (OH) D, bone mineral density (BMD) and relevant clinical data, including the primary disease, age of on-set, gender, smoking, drinking, course of disease, body mass index (BMI), erythrocyte sedimentation rate (ESR) and C--reactive protein (CRP), were retrospectively analyzed. Pearson′s correlation test was used for statistical analysis. Re-sults Serum 25 (OH) D level was negatively correlated with ESR (r=-0.273, P<0.01) and gender (r=-0.330, P<0.01). BMD was negatively correlated with age (r=-0.433, P<0.01). The serum 25 (OH) D level in rheumatoid arthritis (RA) patients was negatively correlated with age (r=-0.781, P<0.01) and BMI (r=-0.681, P<0.01). The BMD in spondy-loarthritis (SpA) patients was negatively correlated with age (r=-0.517, P<0.01) and the course of disease (r=-0.381, P<0.05). Conclusion The serum 25 (OH) D level and BMD in AID patients are significantly correlated with certain clinical indicators, suggesting that proper Vitamin D supplement may be useful in delaying occurrence and develop-ment of the AID. In addition, aggressive treatment of AID is helpful in improving the prognosis.