CAJ | 학술논문

目的：比较精神分裂症患者一级亲属（高危人群）和家族史阴性、首发未用药患者及正常人群之间大脑结构形态的差异。方法：应用基于体素的形态学研究方法（ VBM），对满足入组标准的高危组（患者的一级亲属且无精神症状）10例、首发组（首次发病未用药且家族史阴性）10例及正常人群（正常对照组）10名进行头颅核磁共振扫描和 VBM分析，比较各组之间各脑区灰质体积的变化。结果：与正常对照组相比，高危组左侧扣带回内部和扣带旁回的灰质体积出现显著性缺损（ cluster=26 voxel；MNI：-7，-27，30）；首发组左侧丘脑灰质体积较小（ cluster=580 voxel；MNI：-10，-17，12）。与高危组相比，首发组左侧岛叶灰质体积较小（ cluster=1197 voxel；MNI：-38，-16，-5）。结论：精神分裂症患者大脑结构异常与遗传和环境均有一定的联系。
목적：비교정신분렬증환자일급친속（고위인군）화가족사음성、수발미용약환자급정상인군지간대뇌결구형태적차이。방법：응용기우체소적형태학연구방법（ VBM），대만족입조표준적고위조（환자적일급친속차무정신증상）10례、수발조（수차발병미용약차가족사음성）10례급정상인군（정상대조조）10명진행두로핵자공진소묘화 VBM분석，비교각조지간각뇌구회질체적적변화。결과：여정상대조조상비，고위조좌측구대회내부화구대방회적회질체적출현현저성결손（ cluster=26 voxel；MNI：-7，-27，30）；수발조좌측구뇌회질체적교소（ cluster=580 voxel；MNI：-10，-17，12）。여고위조상비，수발조좌측도협회질체적교소（ cluster=1197 voxel；MNI：-38，-16，-5）。결론：정신분렬증환자대뇌결구이상여유전화배경균유일정적련계。
Objective:By voxel based morphometry( VBM)to compare brain morphological difference between first degree relatives of schizophrenic patients( high-risk group)and negative family history,first-epi-sode,drug-nave patients in schizophrenia and healthy controls. Method:We performed magnetic resonance scanning scans on those meeting the entry criteria for high-risk group(n=10),the first-episode group(n=10) and the normal group( n=10 ),then compared gray matter volume between the groups by VBM. Resuits:Compared with the healthy controls,high-risk group showed significant gray matter volume reduction of the left median cingulate and paracingulate gyri(cluster=26 voxel:MNI:-7,-27,30). Smaller gray matter volume in the left side of the thalamus(cluster=580 voxel:MNI:-10,-17,12)was found in the first-episode group. Compared to high-risk group,first-episode group demonstrated significant gray matter volume reduction of the left insula(cluster=1 197 voxel;MNI:-38,-16,-5). Conciusion:Brain structural abnormalities of schizophrenic patients may be associated with both heredity and environment.