CAJ | 학술논문

诱导多能干细胞（induced Pluripotent Stem Cells，iPSCs）的研究解决了再生医学中运用ESCs所涉及的伦理学问题，为自体再生医学开辟了一条新途径。然而重编程效率的低下成为iPSCs临床转化的重要障碍之一。解析体细胞重编程过程中的分子调控机制对开发高效安全的iPSCs技术具有重要的意义。最近的研究发现microRNA家族在体细胞重编程过程中扮演着重要的角色。本文就涉及体细胞重编程的microRNA，以及对它们在控制体细胞重编程中的潜在角色进行了综述。
유도다능간세포（induced Pluripotent Stem Cells，iPSCs）적연구해결료재생의학중운용ESCs소섭급적윤리학문제，위자체재생의학개벽료일조신도경。연이중편정효솔적저하성위iPSCs림상전화적중요장애지일。해석체세포중편정과정중적분자조공궤제대개발고효안전적iPSCs기술구유중요적의의。최근적연구발현microRNA가족재체세포중편정과정중분연착중요적각색。본문취섭급체세포중편정적microRNA，이급대타문재공제체세포중편정중적잠재각색진행료종술。
Induced pluripotent stem cells (iPSCs) research overcame the ethical issues for using embryo stem cells (ESCs) in regenerative medicine and broke a new path for autologous regenerative medicine. However, the reprogramming efficiency has become one of the most important barriers to iPSCs clinical transformation. Investigation of molecular mechanism during reprogramming process is of great meaning for developing efficient and safe iPS technology. Recently, microRNAs were found playing important roles in reprogramming. In this paper, we focus on microRNAs involved in somatic cell reprogramming and their potential role in this process.