医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2015年
23期
119-119
,共1页
韩桂枝%黄树红%勾洪良%周主华%张冬梅
韓桂枝%黃樹紅%勾洪良%週主華%張鼕梅
한계지%황수홍%구홍량%주주화%장동매
COPD%诱导痰%IL-8%TNF-a
COPD%誘導痰%IL-8%TNF-a
COPD%유도담%IL-8%TNF-a
COPD%Induced sputum%IL-8%TNF-a
目的观察吸入布地奈德福莫特罗对稳定期慢性阻塞性肺疾病(COPD)患者诱导痰中白介素-8、TNF-α水平的影响。方法选择COPD稳定期患者58例，健康对照组26例。 COPD稳定期患者吸入布地奈德福莫特罗，3个月为1疗程。检测患者治疗前后诱导痰中TNF-a、IL-8水平并进行肺功能测定。结果1个疗程后，与治疗前相比，COPD患者诱导痰上清液中TNF-a、IL-8的水平明显降低(<0.01)。治疗后患者肺功能指标(FEFV1%pre,FEV1/FVC%，PEF)明显改善(<0.01)。结论吸入布地奈德福莫特罗可明显改善稳定期COPD患者的肺功能，降低IL-8、TNF-a的表达水平。
目的觀察吸入佈地奈德福莫特囉對穩定期慢性阻塞性肺疾病(COPD)患者誘導痰中白介素-8、TNF-α水平的影響。方法選擇COPD穩定期患者58例，健康對照組26例。 COPD穩定期患者吸入佈地奈德福莫特囉，3箇月為1療程。檢測患者治療前後誘導痰中TNF-a、IL-8水平併進行肺功能測定。結果1箇療程後，與治療前相比，COPD患者誘導痰上清液中TNF-a、IL-8的水平明顯降低(<0.01)。治療後患者肺功能指標(FEFV1%pre,FEV1/FVC%，PEF)明顯改善(<0.01)。結論吸入佈地奈德福莫特囉可明顯改善穩定期COPD患者的肺功能，降低IL-8、TNF-a的錶達水平。
목적관찰흡입포지내덕복막특라대은정기만성조새성폐질병(COPD)환자유도담중백개소-8、TNF-α수평적영향。방법선택COPD은정기환자58례，건강대조조26례。 COPD은정기환자흡입포지내덕복막특라，3개월위1료정。검측환자치료전후유도담중TNF-a、IL-8수평병진행폐공능측정。결과1개료정후，여치료전상비，COPD환자유도담상청액중TNF-a、IL-8적수평명현강저(<0.01)。치료후환자폐공능지표(FEFV1%pre,FEV1/FVC%，PEF)명현개선(<0.01)。결론흡입포지내덕복막특라가명현개선은정기COPD환자적폐공능，강저IL-8、TNF-a적표체수평。
Objective To observe the influence of inhalation budesonide and formoterol to the stable chronic obstructive pulmonary disease(COPD)patients in induced sputum interleukin-8,TNF-αlevel. Methods 58 patients were chosen with stable COPD,and a group of 26 cases were chosen to the health control.Patients who were diagnosed with stable COPD inhaled budesonide and formoterol,and 3 months was for a course of treatment.To test the patients before and after treatment with sputum induction levels of TNF-α,IL-8 and pulmonary function.Results After a period of treatment,patients with COPD in induced sputum supernatant of TNF-α,IL-8 levels significantly decreased ( <0.01),compared with treatment before.The pulmonary function index (FEFV1%pre,FEV1/FVC%,PEF)of the patients improved significantly ( <0.01)after the treatment.Conclusion Inhaling budesonide formoterol obviously improves the pulmonary function in patients with stable COPD,and reduces the expression levels of TNF-αand IL-8.
