CAJ | 학술논문

目的：合成1-甲基-3-甲酰基吲哚-2-甲酸甲酯。方法以吲哚-2-甲酸和甲醇为原料经过酯化反应，甲基化和Vilsmeier-haack反应得到标题化合物，总收率为90.3%。结果本方法具有反应条件温和、收率高、易于纯化的特点，为目标化合物的合成提供了新途径。经过核磁共振氢谱和液相-质谱联用对产物进行了结构表征。结论该工艺具有收率高、操作简单、安全可靠的特点并且为工业化生产提供参考。
목적：합성1-갑기-3-갑선기신타-2-갑산갑지。방법이신타-2-갑산화갑순위원료경과지화반응，갑기화화Vilsmeier-haack반응득도표제화합물，총수솔위90.3%。결과본방법구유반응조건온화、수솔고、역우순화적특점，위목표화합물적합성제공료신도경。경과핵자공진경보화액상-질보련용대산물진행료결구표정。결론해공예구유수솔고、조작간단、안전가고적특점병차위공업화생산제공삼고。
Objective To synthesize methyl 3-formyl-1methyl-1H-indole-2-carboylate. Methods With 1H-indole-2-car-boxylic acid and methanol as starting material, the compound mentioned above was synthesized after esterification as well as reaction of methylation and Vilsmeier-haack, with a total yield of 90. 3%. Results This method boasted the advantages of mild reaction condi-tion, high yield, and easy purification, providing a new way of synthesis of target compound. The structure characterization of the product was completed with 1H-NMR and LC-MS. Conclusion The method has advantages of high yield, simple operation and safe-ty, with reference value for industrialized production. .