重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
18期
2518-2520
,共3页
妊娠并发症%胆汁淤积 ,肝内%中药%治疗效果%半胱氨酸天冬氨酸蛋白酶3
妊娠併髮癥%膽汁淤積 ,肝內%中藥%治療效果%半胱氨痠天鼕氨痠蛋白酶3
임신병발증%담즙어적 ,간내%중약%치료효과%반광안산천동안산단백매3
pregnancy complications%cholestasis,intrahepatic%treatment outcome%caspase 3
目的：探讨中药治疗妊娠期肝内胆汁淤积症（IC P ）的临床疗效。方法将60例IC P患者分为两组：观察组30例以中药茵陈利胆汤联合熊去氧胆酸治疗，对照组30例仅口服熊去氧胆酸药物，疗程均为20 d。对比两组血清总胆汁酸（TBA）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）水平、胎盘组织中Caspase‐3表达及围产儿结局。结果观察组胎盘组织中合体滋养细胞、细胞滋养细胞、蜕膜细胞及间质细胞Caspase‐3表达分别为（10．58±2．62）％、（15．8±4．02）％、（10．17±3．58）％、（14．23±4．39）％明显低于对照组的（20．46±8．68）％、（33．89±7．05）％、（20．56±4．23）％、（28．29±5．58）％，差异有统计学意义（P＜0．05）；两组患者治疗后TBA及ALT、AST均有所下降，观察组疗效优于对照组，差异有统计学意义（P＜0．05），观察组围产儿窒息发生率低于对照组，差异有统计学意义（P＜0．05）。结论中药治疗可以明显降低ICP患者胎盘中Caspase‐3表达及IC P患者的各项生化指标，改善围产儿结局。
目的：探討中藥治療妊娠期肝內膽汁淤積癥（IC P ）的臨床療效。方法將60例IC P患者分為兩組：觀察組30例以中藥茵陳利膽湯聯閤熊去氧膽痠治療，對照組30例僅口服熊去氧膽痠藥物，療程均為20 d。對比兩組血清總膽汁痠（TBA）、天門鼕氨痠氨基轉移酶（AST）、丙氨痠氨基轉移酶（ALT）水平、胎盤組織中Caspase‐3錶達及圍產兒結跼。結果觀察組胎盤組織中閤體滋養細胞、細胞滋養細胞、蛻膜細胞及間質細胞Caspase‐3錶達分彆為（10．58±2．62）％、（15．8±4．02）％、（10．17±3．58）％、（14．23±4．39）％明顯低于對照組的（20．46±8．68）％、（33．89±7．05）％、（20．56±4．23）％、（28．29±5．58）％，差異有統計學意義（P＜0．05）；兩組患者治療後TBA及ALT、AST均有所下降，觀察組療效優于對照組，差異有統計學意義（P＜0．05），觀察組圍產兒窒息髮生率低于對照組，差異有統計學意義（P＜0．05）。結論中藥治療可以明顯降低ICP患者胎盤中Caspase‐3錶達及IC P患者的各項生化指標，改善圍產兒結跼。
목적：탐토중약치료임신기간내담즙어적증（IC P ）적림상료효。방법장60례IC P환자분위량조：관찰조30례이중약인진리담탕연합웅거양담산치료，대조조30례부구복웅거양담산약물，료정균위20 d。대비량조혈청총담즙산（TBA）、천문동안산안기전이매（AST）、병안산안기전이매（ALT）수평、태반조직중Caspase‐3표체급위산인결국。결과관찰조태반조직중합체자양세포、세포자양세포、세막세포급간질세포Caspase‐3표체분별위（10．58±2．62）％、（15．8±4．02）％、（10．17±3．58）％、（14．23±4．39）％명현저우대조조적（20．46±8．68）％、（33．89±7．05）％、（20．56±4．23）％、（28．29±5．58）％，차이유통계학의의（P＜0．05）；량조환자치료후TBA급ALT、AST균유소하강，관찰조료효우우대조조，차이유통계학의의（P＜0．05），관찰조위산인질식발생솔저우대조조，차이유통계학의의（P＜0．05）。결론중약치료가이명현강저ICP환자태반중Caspase‐3표체급IC P환자적각항생화지표，개선위산인결국。
Objective To discuss the efficancy of traditional Chinese medicine in treatment of intrahepatic cholestasis of pregnancy .Methods A total of 60 patients who were admitted to our hospital for severe intrahepatic cholestasis of pregnancy(ICP) from January 2009 to December 2012 were randomly divided into two group using random number table .Patients in study group (n=30) took traditional Chinese medicine three times a day plusUDCA twice a day orally .Patients in control Group (n=30)were on‐ly given UDCA twice a day orally .Conventional treatment and care for ICP were given to both groups .Biochemical index (TBA , ALT ,and AST)level ,pregnancy outcome and Caspase‐3 of the two groups were recorded and compared and compared .Results The expressing of Caspase‐3 in placental cytotrophoblast ,syncytiotrophoblast .Decidual cells and interstitial cells of study group were (10 .58 ± 2 .62)% ,(15 .8 ± 4 .02)% ,(10 .17 ± 3 .58)% ,(14 .23 ± 4 .39)% ,respectively ,which were significantly lower than those in control group(P<0 .05) ,which were (20 .46 ± 8 .68)% ,(33 .89 ± 7 .05)% ,(20 .56 ± 4 .23)% ,(28 .29 ± 5 .58)% .TBA ,ALT、AST in two groups were declined ,and ctedy group was better than in control group(P<0 .05) .The index of liver function were all lower in study group than that of control group(P<0 .05) .Incidence rate of neonatal asphyxia was lower in study group than that of con‐trol group (P<0 .05) .Conclusion Traditonal Chinese medicine can reduce the expression of Caspase‐3 in study group .It is safe and eflfective in the treatment of ICP .
