重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2015年
18期
2477-2479
,共3页
李秀玉%胡波%李忠新
李秀玉%鬍波%李忠新
리수옥%호파%리충신
人乳头瘤病毒%宫颈内皮细胞瘤%T淋巴细胞 ,调节性%细胞凋亡
人乳頭瘤病毒%宮頸內皮細胞瘤%T淋巴細胞 ,調節性%細胞凋亡
인유두류병독%궁경내피세포류%T림파세포 ,조절성%세포조망
human papillomavirus%cervical intraepithelial lesion%T-lymphocytes,regulatory%apoptosis
目的:研究宫颈内皮细胞瘤(CIN)皮损处的CD4+ CD25+ FOXP3+调节性T细胞(Tregs)和 PD‐1+ CD4+ T细胞及其转归之间的关联性。方法用细胞刷从CIN患者收集宫颈淋巴细胞,并用 FACS分析这些细胞中的CD4+ CD25+ FOXP3+T regs和PD‐1+CD4+ T细胞。比较CIN消退者和未消退者之间CD4+ CD25+ FOXP3+ T regs和 PD‐1+ CD4+ T 细胞群的差异。结果宫颈淋巴细胞中CD4+CD25+ FOXP3+ T regs占11.8%,而PD‐1+CD4+ T细胞占30.3%。与未消退者组比较,CIN消退组CD4+CD25+ FOXP3+ Tregs和 PD‐1+ CD4+ T 细胞均明显较低(P<0.05)。结论宫颈 CD4+ CD25+ FOXP3+ Tregs的产生与CIN自发消退成负相关,表明Tregs在人乳头瘤状病毒(HPV)相关的肿瘤免疫逃逸中起重要作用。
目的:研究宮頸內皮細胞瘤(CIN)皮損處的CD4+ CD25+ FOXP3+調節性T細胞(Tregs)和 PD‐1+ CD4+ T細胞及其轉歸之間的關聯性。方法用細胞刷從CIN患者收集宮頸淋巴細胞,併用 FACS分析這些細胞中的CD4+ CD25+ FOXP3+T regs和PD‐1+CD4+ T細胞。比較CIN消退者和未消退者之間CD4+ CD25+ FOXP3+ T regs和 PD‐1+ CD4+ T 細胞群的差異。結果宮頸淋巴細胞中CD4+CD25+ FOXP3+ T regs佔11.8%,而PD‐1+CD4+ T細胞佔30.3%。與未消退者組比較,CIN消退組CD4+CD25+ FOXP3+ Tregs和 PD‐1+ CD4+ T 細胞均明顯較低(P<0.05)。結論宮頸 CD4+ CD25+ FOXP3+ Tregs的產生與CIN自髮消退成負相關,錶明Tregs在人乳頭瘤狀病毒(HPV)相關的腫瘤免疫逃逸中起重要作用。
목적:연구궁경내피세포류(CIN)피손처적CD4+ CD25+ FOXP3+조절성T세포(Tregs)화 PD‐1+ CD4+ T세포급기전귀지간적관련성。방법용세포쇄종CIN환자수집궁경림파세포,병용 FACS분석저사세포중적CD4+ CD25+ FOXP3+T regs화PD‐1+CD4+ T세포。비교CIN소퇴자화미소퇴자지간CD4+ CD25+ FOXP3+ T regs화 PD‐1+ CD4+ T 세포군적차이。결과궁경림파세포중CD4+CD25+ FOXP3+ T regs점11.8%,이PD‐1+CD4+ T세포점30.3%。여미소퇴자조비교,CIN소퇴조CD4+CD25+ FOXP3+ Tregs화 PD‐1+ CD4+ T 세포균명현교저(P<0.05)。결론궁경 CD4+ CD25+ FOXP3+ Tregs적산생여CIN자발소퇴성부상관,표명Tregs재인유두류상병독(HPV)상관적종류면역도일중기중요작용。
Objective This study aims to investigate the correlation of CD4+ CD25+ FOXP3+ Tregs and PD‐1+ CD4+ T cells located at cervical lesions and the prognosis of CIN .PD‐1 expression on T cells induces Tregs .Methods Cervical lymphocytes were collected from CIN patients and analyzed by FACS .Comparisons were made between populations of cervical Tregs and PD‐1+CD4+T cells in CIN regressors and non‐regressors .Results A median of 11 .8% of cervical CD4+ T cells were CD4+ CD25+ FOXP3+Tregs ,while a median of 30 .3% were PD‐1+ CD4+ T cells .The proportions of CD4+ CD25+ FOXP3+ Tregs and PD‐1+ cells were significantly lower in CIN regressors when compared with non‐regressors .Conclusion The prevalence of CD4+ CD25+ FOXP3+Tregs negative correlates with spontaneous regression of CIN ,suggesting that cervical Tregs may play an important role in HPV‐related neoplastic immunoevasion .