CAJ | 학술논문

目的：探讨对早期妊娠孕妇进行糖化血红蛋白（HbA1c）的检测在妊娠期糖尿病（GDM）诊断的过程中的临床意义。方法对2012年1月至12月佛山市三水区妇幼保健院妇产科门诊产检的1847名早孕期妇女检测糖化血红蛋白，同时于孕中期全部进行75 g 葡萄糖耐量试验（OGTT）以确诊 GDM，以 HbA1c≥6为阳性，根据结果分为2组，分别为Ⅰ组阴性组（HbA1c＜6）和Ⅱ组阳性组（HbA1c≥6）。结果1847名早期妊娠妇女的 HbA1c 的平均值为5.22±0.46。Ⅰ组 HbA1c 阴性1715例，经 OGTT 确诊 GDM7例。Ⅱ组 HbA1c 阳性132例，经 OGTT 确诊为GDM48例。通过 HbA1c 检测 GDM 的敏感性为87.27％，特异性为95.31％。2组 GDM 检出率比较，P ＜0．05。结论 HbA1c 在 GDM 诊断中具有重要的临床意义，可以作为早期诊断 GDM 的重要指标。
목적：탐토대조기임신잉부진행당화혈홍단백（HbA1c）적검측재임신기당뇨병（GDM）진단적과정중적림상의의。방법대2012년1월지12월불산시삼수구부유보건원부산과문진산검적1847명조잉기부녀검측당화혈홍단백，동시우잉중기전부진행75 g 포도당내량시험（OGTT）이학진 GDM，이 HbA1c≥6위양성，근거결과분위2조，분별위Ⅰ조음성조（HbA1c＜6）화Ⅱ조양성조（HbA1c≥6）。결과1847명조기임신부녀적 HbA1c 적평균치위5.22±0.46。Ⅰ조 HbA1c 음성1715례，경 OGTT 학진 GDM7례。Ⅱ조 HbA1c 양성132례，경 OGTT 학진위GDM48례。통과 HbA1c 검측 GDM 적민감성위87.27％，특이성위95.31％。2조 GDM 검출솔비교，P ＜0．05。결론 HbA1c 재 GDM 진단중구유중요적림상의의，가이작위조기진단 GDM 적중요지표。
Objective to investigate the early pregnancy test the glycosylated hemoglobin application in the diagnosis of gestational diabetes.Methods we collected 1847 pregnant women of our hospital outpatient service prenatal detec-tion of glycosylated hemoglobin from January 2012 to December 2012,is positive with HbA1c 6 or higher,according to the results are divided into two groups,respectively Ⅰ group (HbA1c<6)and Ⅱ group (HbA1c 6 or higher),the two groups all accepted the glucose tolerance test (OGTT)in diagnosis of GDM,and to follow all the pregnancy outcome. Results Ⅰ group 1715 cases,7 confirmed cases diagnosed with GDM.Ⅱ group 132 cases,48 cases diagnosed with GDM.GDM with HbA1c test sensitivity is 87.27% specificity is 95.31%.2 sets of data for gestational diabetes detec-tion rate comparison(P <0.05).Conclusion HbA1c has important clinical significance in the diagnosis of GDM,can serve as an important index of early diagnosis of GDM.