CAJ | 학술논문

目的：探讨氢波谱（1 HMRS）分析对创伤性颅脑损伤（TCI）的损伤程度及预后的临床指导意义。方法将54例 TCI 患者和10例志愿者行氢波谱检查，分析损伤组与对照组，损伤组患侧与对侧的 N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）、乳酸（Lac）测定值及 NAA／Cho，NAA／Cr，Cho／Cr 比值的变化。结果 NAA／Cho，NAA／Cr 比值损伤组较对照组以及损伤组患侧脑白质较对侧同一部位正常脑白质（NAWM）显著降低，而 Cho／Cr 比值显著升高。NAA／Cho，NAA／Cr，Cho／Cr 比值变化与 TCI 患者 GCS，GOS 具有相关性。结论氢波谱（1 HMRS）分析对创伤性颅脑损伤的早期诊治具有重要的临床指导意义。
목적：탐토경파보（1 HMRS）분석대창상성로뇌손상（TCI）적손상정도급예후적림상지도의의。방법장54례 TCI 환자화10례지원자행경파보검사，분석손상조여대조조，손상조환측여대측적 N-을선천문동안산（NAA）、담감（Cho）、기산（Cr）、유산（Lac）측정치급 NAA／Cho，NAA／Cr，Cho／Cr 비치적변화。결과 NAA／Cho，NAA／Cr 비치손상조교대조조이급손상조환측뇌백질교대측동일부위정상뇌백질（NAWM）현저강저，이 Cho／Cr 비치현저승고。NAA／Cho，NAA／Cr，Cho／Cr 비치변화여 TCI 환자 GCS，GOS 구유상관성。결론경파보（1 HMRS）분석대창상성로뇌손상적조기진치구유중요적림상지도의의。
Objective To investigate the clinical significance of proton magnetic resonance spectroscopy (1 HMRS) on extent and prognosis of traumatic craniocerebral injury (TCI).Methods 30 TCI patients and 10 volunteers were ac-cepted proton magnetic resonance spectroscopy.Observe the change of N-acetyl aspartate (NAA),choline (Cho),crea-tine (Cr),lactate (Lac),NAA/Cho,NAA/ Cr and Cho/Cr of ipsilateral and contralateral white matter of brain.Re-sults The value of NAA/Cho and NAA/Cr in white matter of patients was decreased significantly than control group, however the value of Cho/Cr was significantly increased.The value changes of NAA/Cho,NAA/Cr,Cho/Cr in white matter of patients was correlated with GCS and GOS.Conclusion Proton magnetic resonance spectroscopy has an im-portant guiding significance for the early diagnosis and treatment of traumatic craniocerebral injury.