CAJ | 학술논문

目的：分析妊娠早、中、晚期血清维生素 A、E 水平，评价妊娠期维生素的营养状况，指导孕妇妊娠期合理补充维生素。方法收集2013年1月至2014年8月我院就诊孕妇妊娠早、中、晚期血清样本共10279份，采用高效液相色谱法定量测定血清维生素 A、E 的浓度，并与正常人群血清维生素 A、E 的浓度作比较。结果妊娠早、中、晚期血清维生素 A 检测值分别为（0．33±0．08）mg／L、（0．37±0．10）mg／L、（0．33±0．15）mg／L，总体异常率占25．84％，以缺乏为主要表现（25．38％）。缺乏率在妊娠早期（38．8％）大于妊娠晚期（35．92％）；妊娠早、中、晚期血清维生素 E 检测值分别为（9．12±2．43）mg／L、（14．32±3．54）mg／L、（15．79±5．11）mg／L，总体异常率占6．08％，以过量为主要表现（5．78％）。妊娠早期异常率最低（1．26％），随着孕周增加，维生素 E 异常率也逐渐增加，妊娠晚期达到最高（15.52％），为维生素 E 过量。结论妊娠各期血清维生素 A、E 水平不同，妊娠早期维生素 A 缺乏，而妊娠晚期维生素 E 则存在过量情况，因此重视孕期维生素 A、E 水平监测，合理正确补充，对保障母婴安全有重要意义。
목적：분석임신조、중、만기혈청유생소 A、E 수평，평개임신기유생소적영양상황，지도잉부임신기합리보충유생소。방법수집2013년1월지2014년8월아원취진잉부임신조、중、만기혈청양본공10279빈，채용고효액상색보법정량측정혈청유생소 A、E 적농도，병여정상인군혈청유생소 A、E 적농도작비교。결과임신조、중、만기혈청유생소 A 검측치분별위（0．33±0．08）mg／L、（0．37±0．10）mg／L、（0．33±0．15）mg／L，총체이상솔점25．84％，이결핍위주요표현（25．38％）。결핍솔재임신조기（38．8％）대우임신만기（35．92％）；임신조、중、만기혈청유생소 E 검측치분별위（9．12±2．43）mg／L、（14．32±3．54）mg／L、（15．79±5．11）mg／L，총체이상솔점6．08％，이과량위주요표현（5．78％）。임신조기이상솔최저（1．26％），수착잉주증가，유생소 E 이상솔야축점증가，임신만기체도최고（15.52％），위유생소 E 과량。결론임신각기혈청유생소 A、E 수평불동，임신조기유생소 A 결핍，이임신만기유생소 E 칙존재과량정황，인차중시잉기유생소 A、E 수평감측，합리정학보충，대보장모영안전유중요의의。
Objective To study and analysis of s erum levels of vitamin A,E in early,middle and late pregnancy,E-valuation of vitamin nutritional status in pregnancy,to guide pregnant women vitamin supplements in pregnancy.Meth-ods Collecting total of 10279 serum samples from pregnant women during early,middle and late pregnancy between January 2013 and August 2014 in our hospitol,using High performance liquid chromatography (HPLC)method to quantitative determination of the concentration of serum vitamin A and E,and compared with normal people serum con-centrations of vitamin A,E.Results In early,middle and late pregnancy Vitamin A serum values were 0.33±0.08 mg/L,0.37±0.10 mg/L,0.33±0.15 mg/L,total abnormal rate was 25.84%,main performance is lack(25.38%).Lack of rate in the first trimester of pregnancy (38.8%)is greater than in late pregnancy (35.92%).Vitamin E serum values were 9.12±2.43 mg/L,14.32±3.54 mg/L,15.79±5.11 mg/L,total abnormal rate was 6.08%,with excess(5.78%) as the main performance.Abnormalities in early pregnancy is the lowest (1.26%),with the increase of gestational age, the abnormal rate of vitamin E also gradually increased,reached the highest in late pregnancy (15.52%),all character-ized by excessive vitamin E.Conclusion The serum levels of vitamin A,E are different in pregnancy period,the abnor-mal rate each are not identical,vitamin A is given priority to with lack in the first trimester of pregnancy,while vitamin E is the presence of excess in late pregnancy.Therefore attaching great importance to the monitoring vitamins A,E and other micronutrients level in pregnancy,strengthening perinatal education and guiding the rational correct prenatal vita-mins supplement have important significance to guarantee matenalr and fetal safety.