CAJ | 학술논문

目的：探讨一氧化碳中毒后迟发性脑病（DEACMP）患者血清中白细胞介素4（IL-4）、白细胞介素10（IL-10）、干扰素γ（IFN-γ）、转换生长因子β1（TGF-β1）的水平变化及意义。方法选择40例 DEACMP患者为 A 组，将40例 DEACMP 患者分为轻度认知功能障碍12例，中度认知功能障碍20例，重度认知功能障碍8例。选择40例急性一氧化碳中毒（ACMP）患者为 B 组；另选择同期健康者40名为健康对照组。检测统计受试者血清 IL-4、IL-10、IFN-γ、TGF-β1含量。结果A 组和 B 组血清 IL-4水平为（26．32±4．28）ng／L 和（29．78±4．39）ng／L，低于健康对照组的（40．78±6．82）ng／L（P ＜0．01），B 组血清 IL-10水平为（35．16±6.72）ng／L，高于 A 组的（25．06±5．21）ng／L 和健康对照组的（26．92±5．37）ng／L（P ＜0．01），A 组和 B 组血清 IFN-γ水平为（27．16±9．29）ng／L 和（19．06±8.31）ng／L，高于健康对照组的（12．98±8．15）ng／L（P ＜0.01），且 A 组 IFN-γ水平高于 B 组（P ＜0．01），A 组血清 TGF-β1水平为（32．08±5．62）ng／L，低于 B 组的（52．75±7．61）ng／L 和对照组的（41．08±6．97）ng／L（P ＜0.01）。随着 DEACMP 患者认知障碍的加重，IL-4、IL-10、TGF-β1水平呈下降趋势，IFN-γ水平呈上升趋势（P ＜0．01）。结论DEACMP 患者血清中 IL-4、IL-10、IFN-γ、TGF-β等指标存在异常表达，血清 IL-4、IL-10、IFN-γ、TGF-β1等水平与 DEACMP 患者认知功能障碍程度有关。DEACMP 的发病及进展可能与神经免疫损伤有关。
목적：탐토일양화탄중독후지발성뇌병（DEACMP）환자혈청중백세포개소4（IL-4）、백세포개소10（IL-10）、간우소γ（IFN-γ）、전환생장인자β1（TGF-β1）적수평변화급의의。방법선택40례 DEACMP환자위 A 조，장40례 DEACMP 환자분위경도인지공능장애12례，중도인지공능장애20례，중도인지공능장애8례。선택40례급성일양화탄중독（ACMP）환자위 B 조；령선택동기건강자40명위건강대조조。검측통계수시자혈청 IL-4、IL-10、IFN-γ、TGF-β1함량。결과A 조화 B 조혈청 IL-4수평위（26．32±4．28）ng／L 화（29．78±4．39）ng／L，저우건강대조조적（40．78±6．82）ng／L（P ＜0．01），B 조혈청 IL-10수평위（35．16±6.72）ng／L，고우 A 조적（25．06±5．21）ng／L 화건강대조조적（26．92±5．37）ng／L（P ＜0．01），A 조화 B 조혈청 IFN-γ수평위（27．16±9．29）ng／L 화（19．06±8.31）ng／L，고우건강대조조적（12．98±8．15）ng／L（P ＜0.01），차 A 조 IFN-γ수평고우 B 조（P ＜0．01），A 조혈청 TGF-β1수평위（32．08±5．62）ng／L，저우 B 조적（52．75±7．61）ng／L 화대조조적（41．08±6．97）ng／L（P ＜0.01）。수착 DEACMP 환자인지장애적가중，IL-4、IL-10、TGF-β1수평정하강추세，IFN-γ수평정상승추세（P ＜0．01）。결론DEACMP 환자혈청중 IL-4、IL-10、IFN-γ、TGF-β등지표존재이상표체，혈청 IL-4、IL-10、IFN-γ、TGF-β1등수평여 DEACMP 환자인지공능장애정도유관。DEACMP 적발병급진전가능여신경면역손상유관。
Objective To study changes and meaning of serum IL -4,IL -10,IFN -gamma,TGF -beta 1 level in patients with delayed encephalopathy after carbon monoxide poisoning.Methods From January 2011 and June 2014 in our hospital,40 cases of DEACMP patients were selected as group A;the 40 patients with DEACMP was divided into 12 cases of mild cognitive dysfunction,mild cognitive dysfunction in 20 cases,8 cases of severe cognitive dysfunction.40 cases with acute carbon monoxide poisoning (ACMP)patients were selected as group B;40 cases of healthy subjects were selected as healthy controls.Serum interleukin 4 and interleukin 10(IL -4)(IL -10),interfer-on gamma (IFN -gamma),conversion,growth factor beta 1 (TGF -beta 1)content were tested.Results In Group A and group B serum IL -4 levels were lower than that of healthy controls (P <0.01),and serum levels of IL -10 in group B were higher than that in group A and healthy controls (P <0.01),serum level of IFN -gamma in group A and group B was higher than the healthy controls (P <0.01),and in group A IFN -gamma levels were higher than group B (P <0.01),while in group A serum TGF -beta 1 level was lower than B group and the control group (P <0.01),and in group B TGF -beta 1 level was higher than the control group (P <0.01);With cognitive impairment aggravating of DEACMP patients,IL -4,IL -10,TGF -beta 1 levels were on the decline,and IFN -gamma level was increasing (P <0.01).Conclusion DEACMP patients serum and cerebrospinal fluid of IL -4,IL -10,IFN -gam-ma,TGF -beta measures such as abnormal expression,showed that the onset of DEACMP may be related to neural immune injury.Serum IL -4,IL -10,IFN -gamma and TGF -beta of DEACMP patients exists abnormal expression Serum IL -4,IL -10,IFN -gamma and TGF -beta levels are also related to the degree of cognitive impairment of DEACMP patients.The onset and progress of DEACMP may be associated with neural immune injury.