中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2015年
6期
888-890
,共3页
周玉峰%黄梅%黄晓龙%张健民%张凡喜
週玉峰%黃梅%黃曉龍%張健民%張凡喜
주옥봉%황매%황효룡%장건민%장범희
大鼠%缺氧%脑血流量%一氧化氮%内皮素-1
大鼠%缺氧%腦血流量%一氧化氮%內皮素-1
대서%결양%뇌혈류량%일양화담%내피소-1
Rat%Hypoxia%Cerebral blood flow%Nitric oxide%Endothelin-1
目的:本文主要探讨急性低压缺氧时 NO 和 ET-1对脑血流量变化的调节作用。方法大鼠随机分为平原组和急性低压缺氧组,用电磁血流量计测定脑血流量,用 Gess 法和放免法分别测量血浆和脑 NO2-、ET-1含量,用双波长分光光度法测量 NOS 活性。结果急性低压缺氧时脑血流量、脑含水量、血浆和脑组织 NO2-、ET-1含量、NOS 活性明显增高(P <0.05),脑 ET-1/NO2-比值明显下降(P <0.05)。结论急性低压缺氧时,脑血流量增加, ET-1、NO 均参与了脑血流量变化的调节,NO 血管舒张作用大于 ET-1收缩作用。
目的:本文主要探討急性低壓缺氧時 NO 和 ET-1對腦血流量變化的調節作用。方法大鼠隨機分為平原組和急性低壓缺氧組,用電磁血流量計測定腦血流量,用 Gess 法和放免法分彆測量血漿和腦 NO2-、ET-1含量,用雙波長分光光度法測量 NOS 活性。結果急性低壓缺氧時腦血流量、腦含水量、血漿和腦組織 NO2-、ET-1含量、NOS 活性明顯增高(P <0.05),腦 ET-1/NO2-比值明顯下降(P <0.05)。結論急性低壓缺氧時,腦血流量增加, ET-1、NO 均參與瞭腦血流量變化的調節,NO 血管舒張作用大于 ET-1收縮作用。
목적:본문주요탐토급성저압결양시 NO 화 ET-1대뇌혈류량변화적조절작용。방법대서수궤분위평원조화급성저압결양조,용전자혈류량계측정뇌혈류량,용 Gess 법화방면법분별측량혈장화뇌 NO2-、ET-1함량,용쌍파장분광광도법측량 NOS 활성。결과급성저압결양시뇌혈류량、뇌함수량、혈장화뇌조직 NO2-、ET-1함량、NOS 활성명현증고(P <0.05),뇌 ET-1/NO2-비치명현하강(P <0.05)。결론급성저압결양시,뇌혈류량증가, ET-1、NO 균삼여료뇌혈류량변화적조절,NO 혈관서장작용대우 ET-1수축작용。
Objective The article was to investigate the roles of nitric oxide(NO)and enothelin-1(ET-1)in regula-tion of cerebral blood flow(CBF)during acute hypoxia.Methods Rats were divided into normoxic group(Control)and acute hypoxia(AH),CBF were measured by electromagnetic blood flowmeter,the changes of plasm NO2- ,ET-1 con-tents,brain NO2- ,ET-1 contents and NOS activity were observed.Results Acute hypoxia caused an increase in CBF, plasm NO2- ,ET-1 contents,brain NO2- 、ET-1 contents and NOS activity,the ratio of ET-1/ NO2- in the brain were decreased,as compared with the control group.Conclusion NO and ET-1 may be involved in the regulation of CBF in acute hypoxia,but the NO-dependent vasodilation was stronger than the ET-1-dependent vasoconstriction.