中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2015年
6期
896-899
,共4页
陈馨%陈杰%蒋冰%徐升强
陳馨%陳傑%蔣冰%徐升彊
진형%진걸%장빙%서승강
生长停滞特异性基因产物 6%冠心病%2 型糖尿病%炎症因子
生長停滯特異性基因產物 6%冠心病%2 型糖尿病%炎癥因子
생장정체특이성기인산물 6%관심병%2 형당뇨병%염증인자
Gas 6%coronary heart disease%type 2 diabetes mellitus%inflammatory factor
目的：探讨生长停滞特异性基因产物6（Gas 6）与冠心病伴2型糖尿病患者血清中的变化及其临床意义。方法选择心血管内科120例冠心病患者（CHD）作为冠心病组，120例冠心病伴2型糖尿病患者（CHD＋T2DM）组，同时选择健康体检者80例作为对照组。ELISA 法对三组血清进行 Gas 6的浓度检测，并检测其空腹血糖（FBG）、糖化血红蛋白（HbAlc）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、hs-CRP、同型半胱氨酸（Hcy）含量，并对结果数据进行统计学分析。结果 ELISE 法检测健康对照组 Gas 6的含量为227．61±7．28 pg／ml，冠心病患者组血清中 Gas 6含量为278．57±6．61 pg／ml，冠心病伴2型糖尿病患者血清中 Gas 6含量为285．66±6．37 pg／ml。冠心病患者组和冠心病伴2型糖尿病患者组较健康对照组明显升高，冠心病伴2型糖尿病患者组明显高于冠心病患者组，差异有统计学意义（P ＜0．05）。冠脉狭窄支数越多，血清 Gas 6水平越高（P ＜0．05）。结论生长停滞特异性基因产物6（Gas 6）在冠心病伴2型糖尿病患者血清中浓度明显升高，且随冠脉狭窄支数增多而增高，提示 Gas 6参与冠心病伴2型糖尿病的发生发展。
目的：探討生長停滯特異性基因產物6（Gas 6）與冠心病伴2型糖尿病患者血清中的變化及其臨床意義。方法選擇心血管內科120例冠心病患者（CHD）作為冠心病組，120例冠心病伴2型糖尿病患者（CHD＋T2DM）組，同時選擇健康體檢者80例作為對照組。ELISA 法對三組血清進行 Gas 6的濃度檢測，併檢測其空腹血糖（FBG）、糖化血紅蛋白（HbAlc）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、hs-CRP、同型半胱氨痠（Hcy）含量，併對結果數據進行統計學分析。結果 ELISE 法檢測健康對照組 Gas 6的含量為227．61±7．28 pg／ml，冠心病患者組血清中 Gas 6含量為278．57±6．61 pg／ml，冠心病伴2型糖尿病患者血清中 Gas 6含量為285．66±6．37 pg／ml。冠心病患者組和冠心病伴2型糖尿病患者組較健康對照組明顯升高，冠心病伴2型糖尿病患者組明顯高于冠心病患者組，差異有統計學意義（P ＜0．05）。冠脈狹窄支數越多，血清 Gas 6水平越高（P ＜0．05）。結論生長停滯特異性基因產物6（Gas 6）在冠心病伴2型糖尿病患者血清中濃度明顯升高，且隨冠脈狹窄支數增多而增高，提示 Gas 6參與冠心病伴2型糖尿病的髮生髮展。
목적：탐토생장정체특이성기인산물6（Gas 6）여관심병반2형당뇨병환자혈청중적변화급기림상의의。방법선택심혈관내과120례관심병환자（CHD）작위관심병조，120례관심병반2형당뇨병환자（CHD＋T2DM）조，동시선택건강체검자80례작위대조조。ELISA 법대삼조혈청진행 Gas 6적농도검측，병검측기공복혈당（FBG）、당화혈홍단백（HbAlc）、감유삼지（TG）、고밀도지단백（HDL）、저밀도지단백（LDL）、hs-CRP、동형반광안산（Hcy）함량，병대결과수거진행통계학분석。결과 ELISE 법검측건강대조조 Gas 6적함량위227．61±7．28 pg／ml，관심병환자조혈청중 Gas 6함량위278．57±6．61 pg／ml，관심병반2형당뇨병환자혈청중 Gas 6함량위285．66±6．37 pg／ml。관심병환자조화관심병반2형당뇨병환자조교건강대조조명현승고，관심병반2형당뇨병환자조명현고우관심병환자조，차이유통계학의의（P ＜0．05）。관맥협착지수월다，혈청 Gas 6수평월고（P ＜0．05）。결론생장정체특이성기인산물6（Gas 6）재관심병반2형당뇨병환자혈청중농도명현승고，차수관맥협착지수증다이증고，제시 Gas 6삼여관심병반2형당뇨병적발생발전。
Objective To study the change of growth arrest-specific gene 6 (Gas 6)in serum of coronary heart dis-ease combined with type 2 diabetes mellitus,and clinical significance.Methods We have selected 120 cases of patients with coronary heartdisease(CHD)out of the in-part patients in cardiovascular department as the coronary heart disease group,and 120 cases of patients with coronary heart disease combined with type 2 diabetes mellitus(CHD+T2DM)as coronary heart disease combined with type 2 diabetes mellitus group,80 healthy people were selected as controls.Serum levels of Gas6 were determined by an enzyme-linked immunosorbent assay (ELISA)kit,FBG,HbAlc,triglyceride (TG),high density lipoprotein (HDL),low density lipoprotein (LDL),hs-CRP,homocysteine (Hcy)were detected and the data were statistically analyzed.Results ELISA adopted to detect the content of Gas 6 in the healthy group was 227.61±3.28 pg/ml,in CHD group was 278.57±1.61 pg/ml and in CHD+T2DM group was 285.66±2.37 pg/ml, in CHD group and CHD+T2DM group are significantly higher than the control group,CHD+T2DM group are signifi-cantly higher than the CHD group,and the data has statistically significant (P <0.05).The more the amount of coro-nary stenosis is,the higher level of Gas 6 is(P <0.05).Conclusion The concentraction of growth arrest-specific gene 6 (Gas 6)in serum of coronary heart disease combined with type 2 diabetes mellitus increased evidently and rise with the increase in the number of coronary stenosis,Gas 6 reaction was closely associated with coronary heart disease combined with type 2 diabetes mellitus.
