临床神经病学杂志
臨床神經病學雜誌
림상신경병학잡지
JOURNAL OF CLINICAL NEUROLOGY
2015年
3期
185-187
,共3页
余小骊%刘莉琼%吴豫%王水华%欧阳晓春
餘小驪%劉莉瓊%吳豫%王水華%歐暘曉春
여소려%류리경%오예%왕수화%구양효춘
一氧化碳中毒后迟发性脑病%IL-4%IL-10%γ型干扰素%转化生长因子-β1
一氧化碳中毒後遲髮性腦病%IL-4%IL-10%γ型榦擾素%轉化生長因子-β1
일양화탄중독후지발성뇌병%IL-4%IL-10%γ형간우소%전화생장인자-β1
delayed encephalopathy after carbon monoxide poisoning%IL-4%IL-10%interferon-γ%transforming growth factor-β1
目的：探讨一氧化碳中毒后迟发性脑病（ DEACMP）与神经免疫的相关性。方法应用ELISA法测定30例DEACMP患者（ DEACMP组）、27例急性一氧化碳中毒未发生迟发性脑病患者（ ACOP组）及28例健康对照者（健康对照组）中血清IL－4、IL－10、IFN－γ、TGF－β1的水平并进行比较。结果 IL－4水平DEAC－MP组低于及健康对照组（P＜0．05），ACOP组低于健康对照组（P＜0．05）；IL－10水平DEACMP组低于ACOP组（P＜0．05），ACOP组高于健康对照组（P＜0．05）；IFN－γ水平DEACMP组高于ACOP组及健康对照组（均P＜0．05），ACOP组高于健康对照组（P＜0．05）；TGF－β1水平DEACMP组低于ACOP组及健康对照组（均P＜0．05），ACOP组高于健康对照组（P＜0．05）。结论 DEACMP的发生与神经免疫损伤机制有关。
目的：探討一氧化碳中毒後遲髮性腦病（ DEACMP）與神經免疫的相關性。方法應用ELISA法測定30例DEACMP患者（ DEACMP組）、27例急性一氧化碳中毒未髮生遲髮性腦病患者（ ACOP組）及28例健康對照者（健康對照組）中血清IL－4、IL－10、IFN－γ、TGF－β1的水平併進行比較。結果 IL－4水平DEAC－MP組低于及健康對照組（P＜0．05），ACOP組低于健康對照組（P＜0．05）；IL－10水平DEACMP組低于ACOP組（P＜0．05），ACOP組高于健康對照組（P＜0．05）；IFN－γ水平DEACMP組高于ACOP組及健康對照組（均P＜0．05），ACOP組高于健康對照組（P＜0．05）；TGF－β1水平DEACMP組低于ACOP組及健康對照組（均P＜0．05），ACOP組高于健康對照組（P＜0．05）。結論 DEACMP的髮生與神經免疫損傷機製有關。
목적：탐토일양화탄중독후지발성뇌병（ DEACMP）여신경면역적상관성。방법응용ELISA법측정30례DEACMP환자（ DEACMP조）、27례급성일양화탄중독미발생지발성뇌병환자（ ACOP조）급28례건강대조자（건강대조조）중혈청IL－4、IL－10、IFN－γ、TGF－β1적수평병진행비교。결과 IL－4수평DEAC－MP조저우급건강대조조（P＜0．05），ACOP조저우건강대조조（P＜0．05）；IL－10수평DEACMP조저우ACOP조（P＜0．05），ACOP조고우건강대조조（P＜0．05）；IFN－γ수평DEACMP조고우ACOP조급건강대조조（균P＜0．05），ACOP조고우건강대조조（P＜0．05）；TGF－β1수평DEACMP조저우ACOP조급건강대조조（균P＜0．05），ACOP조고우건강대조조（P＜0．05）。결론 DEACMP적발생여신경면역손상궤제유관。
Objective To explore the relationship between delayed encephalopathy after carbon monoxide poisoning(DEACMP) and neuro-immunology.Methods The serum levels of IL-4、IL-10、interferon-γ(IFN-γ) and transforming growth factor-β1 ( TGF-β1 ) in 30 patients with DEACMP ( DEACMP group ) , 27 patients with acute carbon monoxide poisoning without delayed encephalopathy ( ACOP group ) and 28 healthy controls ( healthy control group) were determined by ELISA .Comparing the results of each group .Results The level of IL-4 in DEACMP was significantly lower than that in healthy control group ( P<0.05) ;and ACOP group was significantly lower than that in healthy control group (P<0.05) .The level of IL-10 in DEACMP was significantly lower than that in ACOP group (P<0.05);and ACOP group was significantly higher than that in healthy control group (P<0.05).The level of IFN-γin DEACMP group was significantly higher than that of ACOP group and healthy control group (all P<0.05);and ACOP group was significantly higher than that in healthy control group ( P<0.05 ) .The level of TGF-β1 in DEACMP group was significantly lower than that of ACOP group and healthy control group ( all P<0.05 ) ;and ACOP group was significantly higher than that of healthy control group ( P<0.05) .Conclusion The occurrence of DEACMP is associated with neural immune mechanism of indury .
